Reduced circulating insulin enhances insulin sensitivity in old mice and extends lifespan
The causal relationships between insulin levels, insulin resistance, and longevity are not
fully elucidated. Genetic downregulation of insulin/insulin-like growth factor 1 (Igf1) signaling …
fully elucidated. Genetic downregulation of insulin/insulin-like growth factor 1 (Igf1) signaling …
Evidence for lifespan extension and delayed age–related biomarkers in insulin receptor substrate 1 null mice
C Selman, S Lingard, AI Choudhury… - The FASEB …, 2008 - Wiley Online Library
Recent evidence suggests that alterations in insulin/insulin–like growth factor 1 (IGF1)
signaling (IIS) can increase mammalian life span. For example, in several mouse mutants …
signaling (IIS) can increase mammalian life span. For example, in several mouse mutants …
Reduced insulin signaling in neurons induces sex-specific health benefits
M Baghdadi, T Nespital, A Mesaros, S Buschbaum… - Science …, 2023 - science.org
Reduced activity of insulin/insulin-like growth factor signaling (IIS) extends health and life
span in mammals. Loss of the insulin receptor substrate 1 (Irs1) gene increases survival in …
span in mammals. Loss of the insulin receptor substrate 1 (Irs1) gene increases survival in …
Adiposity‐independent effects of aging on insulin sensitivity and clearance in mice and humans
N Ehrhardt, J Cui, S Dagdeviren, S Saengnipanthkul… - …, 2019 - Wiley Online Library
Objective Aging is associated with impaired insulin sensitivity and increased prevalence of
type 2 diabetes. However, it remains unclear whether aging‐associated insulin resistance is …
type 2 diabetes. However, it remains unclear whether aging‐associated insulin resistance is …
Insulin/IGF-I-signaling pathway: an evolutionarily conserved mechanism of longevity from yeast to humans
M Barbieri, M Bonafe, C Franceschi… - American Journal of …, 2003 - journals.physiology.org
Although the underlying mechanisms of longevity are not fully understood, it is known that
mutation in genes that share similarities with those in humans involved in the insulin/insulin …
mutation in genes that share similarities with those in humans involved in the insulin/insulin …
[HTML][HTML] Human insulin/IGF-1 and familial longevity at middle age
MP Rozing, RGJ Westendorp, M Frölich, AJM de Craen… - Aging, 2009 - ncbi.nlm.nih.gov
Recently, we have shown that compared to controls, long-lived familial nonagenarians
(mean age: 93.4 years) from the Leiden Longevity Study displayed a lower mortality rate …
(mean age: 93.4 years) from the Leiden Longevity Study displayed a lower mortality rate …
Insulin and aging
A Bartke - Cell cycle, 2008 - Taylor & Francis
In invertebrates, signaling pathways homologous to mammalian insulin and insulin-like
growth factor (IGF-1) signal transduction have a major role in the control of longevity. There …
growth factor (IGF-1) signal transduction have a major role in the control of longevity. There …
The paradox of the insulin/IGF-1 signaling pathway in longevity.
M Rincon, R Muzumdar, G Atzmon… - Mechanisms of ageing …, 2004 - europepmc.org
Ageing may be controlled by a genetic-hormonal system that may have originated from a
very early common ancestor. One of the pathways that has been implicated in ageing is the …
very early common ancestor. One of the pathways that has been implicated in ageing is the …
[HTML][HTML] Insulin, IGF-1 and longevity
D Van Heemst - Aging and disease, 2010 - ncbi.nlm.nih.gov
It has been demonstrated in invertebrate species that the evolutionarily conserved insulin
and insulin-like growth factor (IGF) signaling (IIS) pathway plays a major role in the control of …
and insulin-like growth factor (IGF) signaling (IIS) pathway plays a major role in the control of …
Impaired IGF1R signaling in cells expressing longevity‐associated human IGF1R alleles
Dampening of insulin/insulin‐like growth factor‐1 (IGF1) signaling results in the extension of
lifespan in invertebrate as well as murine models. The impact of this evolutionarily …
lifespan in invertebrate as well as murine models. The impact of this evolutionarily …