The causal relationships between insulin levels, insulin resistance, and longevity are not
fully elucidated. Genetic downregulation of insulin/insulin-like growth factor 1 (Igf1) signaling …

Recent evidence suggests that alterations in insulin/insulin–like growth factor 1 (IGF1)
signaling (IIS) can increase mammalian life span. For example, in several mouse mutants …

Reduced activity of insulin/insulin-like growth factor signaling (IIS) extends health and life
span in mammals. Loss of the insulin receptor substrate 1 (Irs1) gene increases survival in …

Objective Aging is associated with impaired insulin sensitivity and increased prevalence of
type 2 diabetes. However, it remains unclear whether aging‐associated insulin resistance is …

Although the underlying mechanisms of longevity are not fully understood, it is known that
mutation in genes that share similarities with those in humans involved in the insulin/insulin …

Recently, we have shown that compared to controls, long-lived familial nonagenarians
(mean age: 93.4 years) from the Leiden Longevity Study displayed a lower mortality rate …

In invertebrates, signaling pathways homologous to mammalian insulin and insulin-like
growth factor (IGF-1) signal transduction have a major role in the control of longevity. There …

Ageing may be controlled by a genetic-hormonal system that may have originated from a
very early common ancestor. One of the pathways that has been implicated in ageing is the …

It has been demonstrated in invertebrate species that the evolutionarily conserved insulin
and insulin-like growth factor (IGF) signaling (IIS) pathway plays a major role in the control of …

Dampening of insulin/insulin‐like growth factor‐1 (IGF1) signaling results in the extension of
lifespan in invertebrate as well as murine models. The impact of this evolutionarily …