Evolution of Human Brain Left–Right Asymmetry: Old Genes with New Functions

J Wang, S Ma, P Yu, X He - Molecular Biology and Evolution, 2023 - academic.oup.com
The human brain is generally anatomically symmetrical, boasting mirror-like brain regions in
the left and right hemispheres. Despite this symmetry, fine-scale structural asymmetries are …

The genetic architecture of structural left–right asymmetry of the human brain

Z Sha, D Schijven, A Carrion-Castillo, M Joliot… - Nature human …, 2021 - nature.com
Left–right hemispheric asymmetry is an important aspect of healthy brain organization for
many functions including language, and it can be altered in cognitive and psychiatric …

Subtle left-right asymmetry of gene expression profiles in embryonic and foetal human brains

CGF De Kovel, SN Lisgo, SE Fisher, C Francks - Scientific reports, 2018 - nature.com
Left-right laterality is an important aspect of human–and in fact all vertebrate–brain
organization for which the genetic basis is poorly understood. Using RNA sequencing data …

Asymmetric development of the nervous system

A Alqadah, YW Hsieh, ZD Morrissey… - Developmental …, 2018 - Wiley Online Library
The human nervous system consists of seemingly symmetric left and right halves. However,
closer observation of the brain reveals anatomical and functional lateralization. Defects in …

Large-scale phenomic and genomic analysis of brain asymmetrical skew

XZ Kong, M Postema, D Schijven, AC Castillo… - Cerebral …, 2021 - academic.oup.com
The human cerebral hemispheres show a left–right asymmetrical torque pattern, which has
been claimed to be absent in chimpanzees. The functional significance and developmental …

Left-right asymmetry determination in vertebrates

M Mercola, M Levin - Annual Review of cell and developmental …, 2001 - annualreviews.org
▪ Abstract A distinctive and essential feature of the vertebrate body is a pronounced left-right
asymmetry of internal organs and the central nervous system. Remarkably, the direction of …

Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA Consortium

XZ Kong, SR Mathias, T Guadalupe… - Proceedings of the …, 2018 - National Acad Sciences
Hemispheric asymmetry is a cardinal feature of human brain organization. Altered brain
asymmetry has also been linked to some cognitive and neuropsychiatric disorders. Here, the …

[HTML][HTML] Left–right asymmetry in embryonic development: a comprehensive review

M Levin - Mechanisms of development, 2005 - Elsevier
Embryonic morphogenesis occurs along three orthogonal axes. While the patterning of the
anterior–posterior and dorsal–ventral axes has been increasingly well characterized, the left …

Introduction to provocative questions in left–right asymmetry

M Levin, AJS Klar, AF Ramsdell - … Transactions of the …, 2016 - royalsocietypublishing.org
Left–right asymmetry is a phenomenon that has a broad appeal—to anatomists,
developmental biologists and evolutionary biologists—because it is a morphological feature …

Lateralization of the vertebrate brain: taking the side of model systems

ME Halpern, O Güntürkün, WD Hopkins… - Journal of …, 2005 - Soc Neuroscience
Popular culture, from movies, advertising, to self-help books, is captivated by left-brain/right-
brain differences and how these might influence our personalities, moods, and capabilities …