Chemokines and chemokine receptors have been implicated in the pathogenesis of
bronchiolitis. CXCR3 ligands (CXCL10, CXCL9, and CXCL11) were elevated in patients …

Bronchiolitis obliterans syndrome (BOS) is the major limitation to survival post-lung
transplantation and is characterized by a persistent peribronchiolar inflammation that …

The chemokine receptor CXCR6 is highly expressed on lung-derived T cells compared to
blood T cells, especially in inflammatory diseases characterised by T-cell migration to the …

Lung transplantation remains the only effective therapy for patients with end-stage lung
disease, but survival is limited by the development of obliterative bronchiolitis (OB). The …

The chemokine CXCL10 is produced by many inflammatory cells found in the diseased lung
and has been implicated in the pathogenesis of chronic obstructive pulmonary disease …

Aim: To investigate the role of chemokine receptor CXCR3 in cigarette smoking (CS)-
induced pulmonary damage. Methods: CXCR3 knockout (CXCR3-/-) mice were used …

CXCR3 is a chemokine receptor preferentially expressed on lymphocytes, particularly on
type-1 T-lymphocytes. Smokers who develop chronic obstructive pulmonary disease …

The attraction of leukocytes from circulation to inflamed lungs depends on the activation of
both the leukocytes and the resident cells within the lung. In this study we determined gene …

The lung is continuously exposed to bacteria and their products, and has developed a
complex defense mechanism, including neutrophil recruitment. In mice, keratinocyte cell …

We recently demonstrated that human bronchial epithelial cells (HBEC) constitutively
express the CXC chemokine receptor CXCR3, which when activated, induces directed cell …