Tournefolic acid B, derived from Clinopodium chinense (Benth.) Kuntze, protects against myocardial ischemia/reperfusion injury by inhibiting endoplasmic reticulum …

Y Yu, N Xing, X Xu, Y Zhu, S Wang, G Sun, X Sun - Phytomedicine, 2019 - Elsevier
Background Protection the heart from ischemia/reperfusion (I/R) injury is an area of intense
research, as myocardial infarction is a major cause of mortality and morbidity all around the …

Protective effects of total flavonoids from Clinopodium chinense (Benth.) O. Ktze on myocardial injury in vivo and in vitro via regulation of Akt/Nrf2/HO-1 pathway

HJ Zhang, RC Chen, GB Sun, LP Yang, XD Xu, XB Sun - Phytomedicine, 2018 - Elsevier
Abstract Background Clinopodium chinense (Benth.) O. Ktze is a traditional Chinese herbal
medicine, which comprises the plant's total flavonoids. TFCC plays an important role in the …

Baicalein, an active component of Scutellaria baicalensis Georgi, prevents lysophosphatidylcholine-induced cardiac injury by reducing reactive oxygen species …

HM Chen, JH Hsu, SF Liou, TJ Chen, LY Chen… - … and alternative medicine, 2014 - Springer
Background Lysophosphatidylcholine (lysoPC), a metabolite from membrane phospholipids,
accumulates in the ischemic myocardium and plays an important role in the development of …

Cardioprotective effect of breviscapine: inhibition of apoptosis in H9c2 cardiomyocytes via the PI3K/Akt/eNOS pathway following simulated ischemia/reperfusion injury

J Wang, SY Ji, SZ Liu, R Jing… - Die Pharmazie-An …, 2015 - ingentaconnect.com
Breviscapine (BE) is a standardized Chinese herbal medicine extracted from Erigeron
breviscapus (Vant.) Hand.-Mazz. It has been widely used to treat cardiovascular and …

Bauhinia championii flavone inhibits apoptosis and autophagy via the PI3K/Akt pathway in myocardial ischemia/reperfusion injury in rats

J Jian, F Xuan, F Qin, R Huang - Drug Design, Development and …, 2015 - Taylor & Francis
This study aimed to determine the effects of Bauhinia championii flavone (BCF) on
myocardial ischemia/reperfusion injury (MI/RI) in rats and to explore potential mechanisms …

Promoting effect of baicalin on nitric oxide production in CMECs via activating the PI3K-AKT-eNOS pathway attenuates myocardial ischemia–reperfusion injury

J Bai, Q Wang, J Qi, H Yu, C Wang, X Wang, Y Ren… - Phytomedicine, 2019 - Elsevier
Objective Baicalin, which is isolated from Scutellariae Radix, has been shown to possess
therapeutic potential for different diseases. Cardiac microvessel injury in myocardial …

[HTML][HTML] A new flavonoid glycoside (APG) isolated from Clematis tangutica attenuates myocardial ischemia/reperfusion injury via activating PKCε signaling

Y Zhu, S Di, W Hu, Y Feng, Q Zhou, B Gong… - … et Biophysica Acta (BBA …, 2017 - Elsevier
Clematis tangutica has been shown to be beneficial for the heart; however, the mechanism
of this effectremains unknown. Apigenin-7-O-β-D-(-6 ″-p-coumaroyl)-glucopyranoside …

Coptisine protects cardiomyocyte against hypoxia/reoxygenation-induced damage via inhibition of autophagy

Y Wang, Q Wang, LU Zhang, Z Ke, Y Zhao… - Biochemical and …, 2017 - Elsevier
Coptisine is a natural occurring isoquinoline alkaloid isolated from the traditional Chinese
medicinal herb Rhizoma coptidis. Coptisine has been reported to have protective effects on …

Clematichinenoside (AR) attenuates hypoxia/reoxygenation-induced H9c2 cardiomyocyte apoptosis via a mitochondria-mediated signaling pathway

H Ding, R Han, X Chen, W Fang, M Liu, X Wang, Q Wei… - Molecules, 2016 - mdpi.com
Mitochondria-mediated cardiomyocyte apoptosis is involved in myocardial
ischemia/reperfusion (MI/R) injury. Clematichinenoside (AR) is a triterpenoid saponin …

Bauhinia championii Flavone Attenuates Hypoxia-Reoxygenation Induced Apoptosis in H9c2 Cardiomyocytes by Improving Mitochondrial Dysfunction

P Liao, G Sun, C Zhang, M Wang, Y Sun, Y Zhou… - Molecules, 2016 - mdpi.com
This study aimed to determine the effects of Bauhinia championii flavone (BCF) on hypoxia-
reoxygenation (H/R) induced apoptosis in H9c2 cardiomyocytes and to explore potential …