HLA-DRB1* 15: 01 and HLA-DRB3* 02: 02 in PLA2R-related membranous nephropathy

WB Le, JS Shi, T Zhang, L Liu, HZ Qin… - Journal of the …, 2017 - journals.lww.com
Idiopathic membranous nephropathy (MN) is associated with HLA; however, the HLA allele
involved remains unknown. To identify the HLA risk alleles associated with phospholipase …

Genetics of membranous nephropathy

S Gupta, A Köttgen, E Hoxha… - Nephrology Dialysis …, 2018 - academic.oup.com
An HLA-DR3 association with membranous nephropathy (MN) was described in 1979 and
additional evidence for a genetic component to MN was suggested in 1984 in reports of …

PLA2R antibodies, glomerular PLA2R deposits and variations in PLA2R1 and HLA-DQA1 genes in primary membranous nephropathy in South Asians

R Ramachandran, V Kumar, A Kumar… - Nephrology Dialysis …, 2016 - academic.oup.com
Background Antibodies to M-type phospholipase A2 receptor (PLA2R) correlate with clinical
activity of primary membranous nephropathy (PMN). Risk alleles in PLA2R1 and HLA-DQA1 …

Analysis of PLA2R1 and HLA-DQA1 sequence variants in Japanese patients with idiopathic and secondary membranous nephropathy

H Kaga, A Komatsuda, A Omokawa, S Okuyama… - Clinical and …, 2018 - Springer
Background Several recent studies in patients with idiopathic membranous nephropathy
(iMN) from Western and Asian counties showed that some single nucleotide polymorphisms …

Genetic risk variants for membranous nephropathy: extension of and association with other chronic kidney disease aetiologies

P Sekula, Y Li, HC Stanescu, M Wuttke… - Nephrology Dialysis …, 2017 - academic.oup.com
Background: Membranous nephropathy (MN) is a common cause of nephrotic syndrome in
adults. Previous genome-wide association studies (GWAS) of 300 000 genotyped variants …

[HTML][HTML] HLA class II alleles differing by a single amino acid associate with clinical phenotype and outcome in patients with primary membranous nephropathy

H Wang, Z Cui, L Xie, L Zhang, ZY Pei, F Chen, Z Qu… - Kidney international, 2018 - Elsevier
Genome-wide associations and HLA genotyping have revealed associations between HLA
alleles and susceptibility to primary membranous nephropathy. However, associations with …

Phospholipase A2 receptor (PLA2R1) sequence variants in idiopathic membranous nephropathy

MJH Coenen, JM Hofstra, H Debiec… - Journal of the …, 2013 - journals.lww.com
The M-type receptor for phospholipase A2 (PLA2R1) is the major target antigen in idiopathic
membranous nephropathy (iMN). Our recent genome-wide association study showed that …

Interaction between PLA2R1 and HLA-DQA1 variants associates with anti-PLA2R antibodies and membranous nephropathy

J Lv, W Hou, X Zhou, G Liu, F Zhou… - Journal of the …, 2013 - journals.lww.com
Risk alleles at genome loci containing phospholipase A2 receptor 1 (PLA2R1) and HLA-
DQA1 closely associate with idiopathic membranous nephropathy (IMN) in the European …

PLA2R-associated membranous glomerulopathy is modulated by common variants in PLA2R1 and HLA-DQA1 genes

M Saeed, ML Beggs, PD Walker, CP Larsen - Genes & Immunity, 2014 - nature.com
Membranous glomerulopathy (MG) is most commonly caused by autoantibodies directed
against the podocyte phospholipase A2 receptor (PLA2R1) and common variants in this …

Clinicopathological Characteristics and outcomes of PLA2R-associated membranous nephropathy in seropositive patients without pla2r staining on Kidney Biopsy

J Luo, Y Yuan, J Tian, Z Zhou, C Su, F Yang… - American Journal of …, 2022 - Elsevier
Rationale & Objective Phospholipase A 2 receptor (PLA 2 R)–associated membranous
nephropathy (MN) with circulating serum autoantibodies to PLA 2 R (SAb+) but no deposits …