Abstract CD4+ CD25+ Foxp3+ Regulatory T cells (Tregs) play a critical role in immune
tolerance. The plasticity and functional adaptability of Tregs in an inflammatory …

Abstract Foxp3 expressing CD4+ CD25+ regulatory T cells (Tregs) have been shown to
prevent allograft rejection in clinical and animal models of transplantation. However, the role …

Background Protective CD4+ CD25+ regulatory T cells bearing the Forkhead Foxp3
transcription factor can now be divided into three subsets: Endogenous thymus-derived …

Regulatory T (Treg) cells play an essential role in maintaining immunological tolerance. The
discovery of FoxP3 as a key Treg transcription factor combined with recent advances in the …

Foxp3+ CD4+ regulatory T cells (Treg) have a crucial role in controlling CD4+ T-cell
activation, proliferation, and effector function. However, the molecular mechanisms …

Abstract CD4+ CD25+ FOXP3+ regulatory T cells (Treg) are pivotal for peripheral self-
tolerance. They prevent immune responses to auto-and alloantigens and are thus under …

The emerging notion of environment-induced reprogramming of Foxp3+ regulatory T (Treg)
cells into helper T (Th) cells remains controversial. By genetic fate mapping or adoptive …

Foxp3-lineage CD4 regulatory T cells (Tregs) were named for their ability to maintain self
tolerance and suppress T cell immunity. However, resting Tregs from noninflamed tissues …

The immune system protects itself from autoreactivity by maintaining a balance between
effector and Treg responses. Peripheral induction of Treg is one mechanism by which this …

Foxp3 specifies the T reg cell lineage and is indispensable for immune tolerance.
Accordingly, rare Foxp3 mutations cause lethal autoimmunity. The mechanisms precipitating …