With the widespread use of Integrase strand transfer inhibitors (INSTIs), surveillance of HIV-
1 pretreatment drug resistance is critical in optimizing antiretroviral treatment efficacy …

Background Although biochemical analysis of HIV-1 integrase enzyme suggested the use of
integrase inhibitors (INIs) against HIV-1C, different viral subtypes may favor different …

The World Health Organization (WHO) has put forth recommendations for the use of
integrase (IN) strand transfer inhibitors (INSTIs) to be part of the first-line combination …

Abstract Objectives In Cameroon, the integrase (IN) strand transfer inhibitor (INSTI)
dolutegravir was recently introduced for the treatment of HIV-1 infection. Since pretreatment …

HIV‐1 genetic diversity and drug resistance mutations remain public health challenges
especially in regions where treatment is limited. The aim of this study was to characterize the …

HIV-Integrase (IN) has proven to be a viable target for highly specific HIV-1 therapy. We
aimed to characterize the HIV-1 IN gene in a South African context and identify resistance …

Objectives Integrase strand transfer inhibitors (INSTIs) have been recently recommended as
the preferred first-line option for antiretroviral treatment initiators in low-and middle-income …

Integrase strand-transfer inhibitors (INSTIs) are now included in preferred first-line
antiretroviral therapy (ART) for HIV-infected adults. Studies of Western clade-B HIV-1 show …

Previously used as part of salvage therapy, integrase strand transfer inhibitors (INSTIs) have
become part of the preferred antiretroviral therapy (ART) first-line regimen in most low-to …

The Indian national AIDS control program heavily relies on low cost nucleoside reverse
transcriptase inhibitor (NRTI) and non-nucleoside reverse transcriptase inhibitor (NNRTI) …