Motivation: Identifying and prioritizing somatic mutations is an important and challenging
area of cancer research that can provide new insights into gene function as well as new …

Background The initiation and subsequent evolution of cancer are largely driven by a
relatively small number of somatic mutations with critical functional impacts, so-called driver …

Identifying driver mutations in cancer is notoriously difficult. To date, recurrence of a mutation
in patients remains one of the most reliable markers of mutation driver status. However …

Sequencing has identified millions of somatic mutations in human cancers, but
distinguishing cancer driver genes remains a major challenge. Numerous methods have …

Optimal methods could effectively improve the accuracy of predicting and identifying
candidate driver genes. Various computational methods based on mutational frequency …

Identifying the genes and mutations that drive the emergence of tumors is a critical step to
improving our understanding of cancer and identifying new directions for disease diagnosis …

The traditional view of cancer as a genetic disease that can successfully be treated with
drugs targeting mutant onco-proteins has motivated whole-genome sequencing efforts in …

It is complicated to identify cancer-causing mutations. The recurrence of a mutation in
patients remains one of the most reliable features of mutation driver status. However, some …

Motivation Comprehensive catalogue of genes that drive tumor initiation and progression in
cancer is key to advancing diagnostics, therapeutics and treatment. Given the complexity of …

The vast amount of available sequencing data allows the scientific community to explore
different genetic alterations that may drive cancer or favor cancer progression. Software …