Background Colorectal cancer is one of the most common cancers in the United States with
an early detection rate of only 39%. Colorectal cancer cells along with other cancer cells …

Background: Gap junctional intercellular communication (GJIC) is a mechanism for direct
cell-to-cell signalling and is mediated by gap junctions, which consist of transmembrane …

Background Intercellular communication via gap junctions, composed of protein subunits
called connexins (Cxs), plays a key role in controlling cell growth, differentiation and …

This article is the first to show that loss of connexin43 (Cx43) expression in colorectal tumors
is correlated with significantly shorter relapse‐free and overall survival. Cx43 was further …

The aim of this study was the assessment of expression and location of CX32 and CX43 in
colorectal adenomas and carcinomas as well as analysis of expression of these proteins in …

Background Gap junction intercellular communication (GJIC) is considered to play a role in
the regulation of homeostasis because it regulates important processes, such as cell …

A gradual loss of functional gap junction between tumor cells has been reported with
colorectal cancer (CRC) progression. Here, we explored if colon cancer cells could also …

Objectives. Gap junctional intercellular communication (GJIC) is believed to play an
important role in the maintenance of cell homeostasis, and its disruption may be associated …

Connexins (Cxs) are critical for normal tissue development, differentiation, and cell
proliferation. Normal expression and function of Cxs are considered to play a role in tumor …

Background Gap junctions, as one of the major ways to maintain social connections
between cells, are now considered as one of the potential regulators of tumor metastasis …