Group I metabotropic glutamate receptors (mGluRs) have been implicated in the
pathophysiology of central nervous system injury, but the role of mGluR5 in traumatic brain …

Several previous studies utilizing selective pharmacological antagonists have demonstrated
that type 5 metabotropic glutamate receptors (mGluR5) are potential therapeutic targets for …

Traumatic brain injury (TBI)-released excessive glutamate resulted in the activation of
glutamate receptors including the metabotropic glutamate receptor 5 (mGluR5). To …

The role of phospholipase C-coupled (group I) metabotropic glutamate receptors (mGluR1
and mGluR5) in post-traumatic neuronal injury was examined using rat in vivo and in vitro …

The effects of selective blockade of group I metabotropic glutamate receptor subtype 1
(mGluR1) on neuronal cell survival and post-traumatic recovery was examined using rat in …

Activation of metabotropic glutamate receptor 5 (mGluR5) provided neuroprotection in
multiple central nervous system injury, but the roles of mGluR5 in subarachnoid hemorrhage …

The effects of group II mGluR activation by selective agonist (–)-2-oxa-4-aminobicyclo [3.1.
0] hexane-4, 6-dicarboxylate (LY379268) were examined in a mouse model of controlled …

Traumatic brain injury (TBI) induces microglial activation, which can contribute to secondary
tissue loss. Activation of mGluR5 reduces microglial activation and inhibits microglial …

A wealth of evidence has shown that microglia-associated neuro-inflammation is involved in
the secondary brain injury contributed to the poor outcome after traumatic brain injury (TBI) …

Traumatic brain injury (TBI) causes microglial activation and related neurotoxicity that
contributes to chronic neurodegeneration and loss of neurological function. Selective …