Sideroflexins (SLC56 family) are highly conserved multi-spanning transmembrane proteins
inserted in the inner mitochondrial membrane in eukaryotes. Few data are available on their …

Abstract The sigma-2 receptor (S2R) is a potential therapeutic target for cancer and
neuronal diseases. However, the identity of the S2R has remained a matter of debate …

Background: Widespread protein aggregation occurs in the living system under stress or
during aging, owing to disturbance of endoplasmic reticulum (ER) proteostasis. Many …

One distinguishing feature of eukaryotic cells is their compartmentalization into organelles,
which all have a unique structural and functional identity. Some proteins are exclusively …

Background Lung cancer is the leading cause of cancer-related death worldwide. The sex
differences in the occurrence and fatality rates of non-small cell lung cancer (NSCLC), along …

Ferroptosis is iron-dependent oxidative cell death. Labile iron and polyunsaturated fatty acid
(PUFA)-containing lipids are two critical factors for ferroptosis execution. Many processes …

Steroids synthesized in the periphery or de novo in the brain, so called 'neurosteroids', exert
both genomic and nongenomic actions on neurotransmission systems. Through rapid …

Sigma-1 receptor (Sig-1R) is located in the endoplasmic reticulum (ER) and clustered on the
mitochondria related endoplasmic membranes, which are involved in the regulation of …

The sigma‐2 receptor is highly expressed in various rapidly proliferating cancer cells and
regarded as a cancer cell biomarker. Selective sigma‐2 ligands have been shown to …

Sigma-1 receptors are molecular chaperones that may act as pathological mediators and
targets for novel therapeutic applications in neurodegenerative diseases. Accumulating …