Somatostatin (SST) via five Gi coupled receptors namely SSTR1-5 is known to inhibit cell
proliferation by cytostatic and cytotoxic mechanisms. Heterodimerization plays a crucial role …

Activation of phosphotyrosine phosphatases (PTPs) by somatostatin receptor (SSTR)
represents one of the main intracellular mechanisms involved in the antiproliferative effect of …

The current study examines the relationship between ERRα1 and the Sp1 transcription
factor. The transfection of ERRα1 enhances Sp1–DNA complex formation as visualized by …

SFT (stimulator of Fe transport) is a novel transport protein that has been found to facilitate
uptake of iron presented to cells as either Fe (II) or Fe (III). When HeLa cells are exposed to …

The pharmacological effects (ie, inhibition of endocrine secretion and cell proliferation)
mediated by the hormone somatostatin (SRIF) are derived from its universal high-affinity …

The ability of both somatostatin (SS) and its stable analogues to inhibit cell growth depends
on the stimulation of specific membrane receptors (SSTR1-5), which belong to the G protein …

Abstract Sigma-1 receptor (Sig-1R) is molecular chaperone regulating calcium efflux from
the neuronal endoplasmic reticulum to mitochondria. Recent studies show that Sig-1R …

Depression and cognitive disorders are diseases with complex and not-fully understood
etiology. Unfortunately, the COVID-19 pandemic dramatically increased the prevalence of …

Activation of the somatostatin receptor sst2, a member of the G i protein-coupled receptor
family, results in the stimulation of a protein-tyrosine phosphatase activity involved in the …

The G protein-coupled sst2 somatostatin receptor acts as a negative cell growth regulator.
Sst2 transmits antimitogenic signaling by recruiting and activating the tyrosine phosphatase …