New aspects of oxytocin receptor function revealed by knockout mice: sociosexual behaviour and control of energy balance

K Nishimori, Y Takayanagi, M Yoshida… - Progress in brain …, 2008 - Elsevier
To further define the function of the oxytocin receptor (OXTR) in vivo, we generated mice
deficient in the Oxtr gene (Oxtr−/−). Oxtr−/− mice had no obvious deficits in fertility or sexual …

Oxytocin receptor gene variation predicts empathic concern and autonomic arousal while perceiving harm to others

KE Smith, EC Porges, GJ Norman, JJ Connelly… - Social …, 2014 - Taylor & Francis
Recent research indicates that the neuropeptide oxytocin and the gene for the oxytocin
receptor (OXTR) have been implicated in the modulation of various social behaviors …

Oxytocin enhancement of emotional empathy: generalization across cultures and effects on amygdala activity

Y Geng, W Zhao, F Zhou, X Ma, S Yao… - Frontiers in …, 2018 - frontiersin.org
Accumulating evidence suggests that the neuropeptide oxytocin (OXT) can enhance
empathy although it is unclear which specific behavioral and neural aspects are influenced …

Social touch promotes interfemale communication via activation of parvocellular oxytocin neurons

Y Tang, D Benusiglio, A Lefevre, L Hilfiger… - Nature …, 2020 - nature.com
Oxytocin (OT) is a great facilitator of social life but, although its effects on socially relevant
brain regions have been extensively studied, OT neuron activity during actual social …

Oxytocin increases amygdala reactivity to threatening scenes in females

A Lischke, M Gamer, C Berger, A Grossmann… - …, 2012 - Elsevier
The neuropeptide oxytocin (OT) is well known for its profound effects on social behavior,
which appear to be mediated by an OT-dependent modulation of amygdala activity in the …

Oxytocin and the neural mechanisms regulating social cognition and affiliative behavior

HE Ross, LJ Young - Frontiers in neuroendocrinology, 2009 - Elsevier
Oxytocin is produced in the hypothalamus and released into the circulation through the
neurohypophyseal system. Peripherally released oxytocin facilitates parturition and milk …

Oxytocin receptor genetic variation relates to empathy and stress reactivity in humans

SM Rodrigues, LR Saslow, N Garcia… - Proceedings of the …, 2009 - National Acad Sciences
Oxytocin, a peptide that functions as both a hormone and neurotransmitter, has broad
influences on social and emotional processing throughout the body and the brain. In this …

Oxytocin and the oxytocin receptor underlie intrastrain, but not interstrain, social recognition

AH Macbeth, HJ Lee, J Edds… - Genes, Brain and …, 2009 - Wiley Online Library
We studied three lines of oxytocin (Oxt) and oxytocin receptor (Oxtr) knockout (KO) male
mice [Oxt−/−, total Oxtr−/− and partial forebrain Oxtr (OxtrFB/FB)] with established deficits in …

Oxytocin and parental behaviors

C Yoshihara, M Numan, KO Kuroda - Behavioral pharmacology of …, 2018 - Springer
The oxytocin/vasopressin ancestor molecule has been regulating reproductive and social
behaviors for more than 500 million years. In all mammals, oxytocin is the hormone …

Oxytocin and the salience of social cues

BB Averbeck - Proceedings of the National Academy of …, 2010 - National Acad Sciences
The neuropeptide oxytocin (OT) is rapidly moving from a molecule with interesting effects in
model systems to an important mediator of a range of human social behaviors. In this issue …