The default mode network in healthy aging and Alzheimer′ s disease

K Mevel, G Chételat, F Eustache… - International journal of …, 2011 - Wiley Online Library
In the past decade, a “default mode network”(DMN) has been highlighted in neuroimaging
studies as a set of brain regions showing increased activity in task‐free state compared to …

Alzheimer's disease and amnestic mild cognitive impairment weaken connections within the default-mode network: a multi-modal imaging study

DC Zhu, S Majumdar, IO Korolev… - Journal of …, 2013 - content.iospress.com
We applied a multi-modal imaging approach to examine structural and functional alterations
in the default-mode network (DMN) that are associated with Alzheimer's disease (AD) and …

[HTML][HTML] Imaging the default mode network in aging and dementia

A Hafkemeijer, J van der Grond… - Biochimica et Biophysica …, 2012 - Elsevier
Although in the last decade brain activation in healthy aging and dementia was mainly
studied using task-activation fMRI, there is increasing interest in task-induced decreases in …

Effective connectivity in the default mode network is distinctively disrupted in Alzheimer's disease—a simultaneous resting‐state FDG‐PET/fMRI study

M Scherr, L Utz, M Tahmasian, L Pasquini… - Human brain …, 2021 - Wiley Online Library
A prominent finding of postmortem and molecular imaging studies on Alzheimer's disease
(AD) is the accumulation of neuropathological proteins in brain regions of the default mode …

Functional MRI assessment of task‐induced deactivation of the default mode network in Alzheimer's disease and at‐risk older individuals

M Pihlajamäki, RA Sperling - Behavioural neurology, 2009 - Wiley Online Library
Alzheimer's disease (AD) is the most common form of dementia in old age, and is
characterized by prominent impairment of episodic memory. Recent functional imaging …

Amyloid plaques disrupt resting state default mode network connectivity in cognitively normal elderly

YI Sheline, ME Raichle, AZ Snyder, JC Morris… - Biological …, 2010 - Elsevier
BACKGROUND: Important functional connections within the default mode network (DMN)
are disrupted in Alzheimer's disease (AD), likely from amyloid-beta (Aβ) plaque-associated …

Age-related changes in the default mode network are more advanced in Alzheimer disease

DT Jones, MM Machulda, P Vemuri, EM McDade… - Neurology, 2011 - AAN Enterprises
Objective: To investigate age-related default mode network (DMN) connectivity in a large
cognitively normal elderly cohort and in patients with Alzheimer disease (AD) compared with …

Default-mode network activity distinguishes Alzheimer's disease from healthy aging: evidence from functional MRI

MD Greicius, G Srivastava… - Proceedings of the …, 2004 - National Acad Sciences
Recent functional imaging studies have revealed coactivation in a distributed network of
cortical regions that characterizes the resting state, or default mode, of the human brain …

Functional disintegration of the default mode network in prodromal Alzheimer's disease

KNH Dillen, HIL Jacobs, J Kukolja… - Journal of …, 2017 - content.iospress.com
Neurodegenerative brain changes can affect the functional connectivity strength between
nodes of the default-mode network (DMN), which may underlie changes in cognitive …

[HTML][HTML] Deficits in episodic memory retrieval reveal impaired default mode network connectivity in amnestic mild cognitive impairment

CJ Dunn, SL Duffy, IB Hickie, J Lagopoulos… - NeuroImage: Clinical, 2014 - Elsevier
Amnestic mild cognitive impairment (aMCI) is believed to represent a transitional stage
between normal healthy ageing and the development of dementia. In particular, aMCI …