In our earlier results, we demonstrated that cells expressing the complement C5aR are
vulnerable since abnormal activation of C5aR caused apoptosis of these cells. In this study …

The present studies were undertaken to determine whether neuronal subsets in normal
brains constitutively express functionally competent C5a receptors. In situ hybridization …

Background Alzheimer's disease (AD) is a neurodegenerative dementia characterized by
the decline of cognition and the presence of neuropathological changes including neuronal …

There is evidence that the complement system, a major component of inflammatory
responses, may play an important role in neurodegenerative conditions such as Alzheimer's …

Alzheimer's disease (AD) is an age-related dementia, characterized by amyloid plaques,
neurofibrillary tangles, neuroinflammation, and neuronal loss in the brain. Components of …

To investigate the role of C5a generated on complement activation in brain, the lupus model,
MRL/lpr mice were treated with C5a receptor (R) antagonist (ant). Neutrophil infiltration …

Multiple studies have recognized the involvement of the complement cascade during
Alzheimer's disease pathogenesis. However, the specific role of C5a-C5aR1 signaling in the …

The complement system is thought to be involved in the pathogenesis of numerous
neurological diseases, although its precise role remains controversial. In this study we used …

The complement system, an important part of the innate immune system, provides protection
against invading pathogens, in part through its proinflammatory activities. Although most …

Background Complement component C5-derived C5a locally generated in the brain has
been shown to protect against glutamate-induced neuronal apoptosis and beta-amyloid (Aβ) …