The present study aims to examine the effect of low-dose ionizing irradiation on DNA double
strand breaks (DSB) in mouse spermatogonial stem cells (SSCs) and reveal the underlying …

Abstract 53BP1 mediates DNA repair process in somatic cells; however, the function of
53BP1 in germline stem cells still remains unclear. In the present study, animals and cells …

Purpose Testicular spermatogenesis is extremely sensitive to radiation-induced damage,
and even low scattered doses to testis from radiation therapy may pose reproductive risks …

Neonatal gonocytes are the precursors of both spermatogonial stem cells and
spermatogonia; thus, any persistant DNA damage in these cells may lead to heritable …

Background The present study aimed to investigate the mechanism of low-dose ionizing
radiation (IR) induced apoptosis of undifferentiated spermatogonia in vivo and in vitro …

The present study was designed to detect DNA repair response through the homologous
recombination pathway in mouse spermatogonial stem cells. Mouse spermatogonial stem …

Accurate quantification of DNA double strand breaks (DSB) in testicular germ cells is difficult
because of cellular heterogeneity and the presence of endogenous γH2AX. Here, we used …

Germ cells are thought to exhibit a unique DNA damage response that differs from that of
somatic stem cells, and previous studies suggested that Trp53 is not involved in the survival …

Spermatogenesis is a complex developmental process. During this process, male germ cells
from spermatogonia to sperm cells encounter a number of DNA damages. The most severe …

DNA damage response in adult spermatogenic cells should limit the propagation of
mutations to the offspring, without being detrimental to fertility. In differentiating …