Hypovasculature is an outstanding characteristic of pancreatic cancers in imaging
diagnosis, suggesting that blood supply is poor in pancreatic cancer tissues. Despite poor …

In the tumor cells exposed to hypoxia, hypoxia-inducible factor-1 (HIF-1)-mediated
adaptation responses such as angiogenesis and anaerobic metabolism are induced for their …

Purpose: Pancreatic cancer is characterized by intratumoral hypoxia, early and aggressive
local invasion, and metastatic potential. Hypoxia-inducible factor-1 (HIF-1) is the major …

Abstract Hypoxia inducible factor-1 (HIF-1) is the major transcription factor and key regulator
of adoptive responses to hypoxia. Although it usually promotes tumor cell survival under …

Aims To determine whether hypoxia-inducible factor 1 (HIF-1) is specifically activated by
hypoxia in vitro in pancreatic cancer cells and correlated these findings with tumor …

Background: Intratumoral hypoxia is known to lead to increased aggressiveness and distant
metastasis. However, the interplay underlying these actions is still unknown. Objective: We …

Pancreatic cancer is one of the leading causes of cancer-related deaths worldwide and is
characterized by highly hypoxic tumor microenvironment. Hypoxia-inducible factor-1 alpha …

Background and aims Pancreatic cancer is characterized by inadequate vascularization and
considerable tumor hypoxia is prevalent. However, whether hypoxia-inducible factor 1α (HIF …

There is accumulating evidence demonstrating that HIF-1 functions as a key regulator of the
adaptation responses to hypoxia in cancer tissues. To this evidence, we add that adaptation …

Background Hypoxia-inducible transcription factor-1α (HIF-1α), which plays an important
role in controlling the hypoxia-induced glycolysis pathway, is a" master" gene in the tissue …