Major psychiatric disorders, including attention deficit hyperactivity disorder (ADHD), autism
(AUT), bipolar disorder (BD), major depressive disorder (MDD), and schizophrenia (SZ), are …

Abstract Schizophrenia (SCZ), bipolar disorder (BD), and major depressive disorder (MDD)
are heritable psychiatric disorders with partially overlapping genetic liability. Shared and …

Pleiotropy occurs when a genetic variant influences more than one trait. This is a key
property of the genomic architecture of psychiatric disorders and has been observed for rare …

Psychiatric illnesses are complex and polygenic. They are associated with widespread
alterations in the brain, which are partly influenced by genetic factors. There have been …

Background Mental health and cognitive achievement are partly heritable, highly polygenic,
and associated with brain variations in structure and function. However, the underlying …

Background Polygenicity and genetic heterogeneity pose great challenges for studying
psychiatric conditions. Genetically informed approaches have been implemented in …

In the past decade, imaging genetics has evolved into a highly successful neuroimaging
discipline with a variety of sophisticated research tools. To date, several neural systems …

Background Attention-deficit/hyperactivity disorder (ADHD) has substantial heritability, and a
recent large-scale investigation has identified common genome-wide significant loci …

Evidence suggests that there is shared genetic aetiology across the major psychiatric
disorders conferred by additive effects of many common variants. Measuring their joint …

Cytoarchitectural abnormalities have been described in the prefrontal cortex (PFC) of
subjects with psychiatric disorders. We explored the possible genetic causalities that may …