Approximately two-thirds of the US population are overweight, which means that insulin
resistance is probably the most common metabolic abnormality in the USA. I propose three …

Insulin resistance is a major metabolic feature of obesity and is a key factor in the etiology of
a number of diseases, including type 2 diabetes. In this review, we discuss potential …

It is widely accepted that increasing adiposity is associated with insulin resistance and
increased risk of type 2 diabetes. The predominant paradigm used to explain this link is the …

The dark side of glucose Page 1 TG 1995 Nature Publishing Group http://www.nature.com/naturemedicine
NEWS S VIEWS ------------ The dark side of glucose Non-enzymatic glycation, cellular receptors …

Obesity contributes to the development of type 2 diabetes, but the underlying mechanisms
are poorly understood. Using cell culture and mouse models, we show that obesity causes …

Insulin has important vascular actions to stimulate production of nitric oxide from
endothelium. This leads to capillary recruitment, vasodilation, increased blood flow, and …

The role of different tissues in insulin action and their contribution to the pathogenesis of
diabetes remain unclear. To examine this question, we have used genetic reconstitution …

Obesity genes and insulin resistance : Current Opinion in Endocrinology, Diabetes and
Obesity Obesity genes and insulin resistance : Current Opinion in Endocrinology, Diabetes …

Obesity is a major health risk factor, and obesity-induced morbidity and complications
account for huge costs for affected individuals, families, healthcare systems, and society at …

Atherosclerosis, a pathological process that underlies the development of cardiovascular
disease, is the primary cause of morbidity and mortality in patients with type 2 diabetes …