Insulin action and the insulin signaling network
B Cheatham, CR Kahn - Endocrine reviews, 1995 - academic.oup.com
I. Introduction IN THE fasted state, glucose homeostasis depends upon the balance between
hepatic glucose production and glucose utilization by the major insulin-dependent tissues …
hepatic glucose production and glucose utilization by the major insulin-dependent tissues …
[HTML][HTML] IRS1-independent defects define major nodes of insulin resistance
Insulin resistance is a common disorder caused by a wide variety of physiological insults,
some of which include poor diet, inflammation, anti-inflammatory steroids, hyperinsulinemia …
some of which include poor diet, inflammation, anti-inflammatory steroids, hyperinsulinemia …
Mechanisms of insulin resistance in obesity
J Ye - Frontiers of medicine, 2013 - Springer
Obesity increases the risk for type 2 diabetes through induction of insulin resistance.
Treatment of type 2 diabetes has been limited by little translational knowledge of insulin …
Treatment of type 2 diabetes has been limited by little translational knowledge of insulin …
Impaired ('diabetic') insulin signaling and action occur in fat cells long before glucose intolerance—is insulin resistance initiated in the adipose tissue?
U Smith - International journal of obesity, 2002 - nature.com
This review postulates and presents recent evidence that insulin resistance is initiated in the
adipose tissue and also suggests that the adipose tissue may play a pivotal role in the …
adipose tissue and also suggests that the adipose tissue may play a pivotal role in the …
Series introduction: the molecular and physiological basis of insulin resistance: emerging implications for metabolic and cardiovascular diseases
AR Saltiel - The Journal of clinical investigation, 2000 - Am Soc Clin Investig
Following the discovery of insulin by Banting and Best in 1922, it was widely assumed that
human diabetes was due exclusively to a deficiency in the secretion of the hormone …
human diabetes was due exclusively to a deficiency in the secretion of the hormone …
Monogenic forms of insulin resistance: apertures that expose the common metabolic syndrome
RA Hegele - Trends in Endocrinology & Metabolism, 2003 - cell.com
Insulin resistance is common and plays a central role in the pathogenesis of type 2 diabetes
mellitus (T2DM). Precedents in biomedical research indicate that evaluation of monogenic …
mellitus (T2DM). Precedents in biomedical research indicate that evaluation of monogenic …