Different synaptic and subsynaptic localization of adenosine A2A receptors in the hippocampus and striatum of the rat

N Rebola, PM Canas, CR Oliveira, RA Cunha - Neuroscience, 2005 - Elsevier
Adenosine A2A receptors are most abundant in the striatum where they control the
striatopallidal pathway thus controlling locomotion. Extra-striatal A2A receptors are …

Adenosine A1 and A2A receptors are co-expressed in pyramidal neurons and co-localized in glutamatergic nerve terminals of the rat hippocampus

N Rebola, RJ Rodrigues, LV Lopes, PJ Richardson… - Neuroscience, 2005 - Elsevier
Adenosine is a neuromodulator that controls neurotransmitter release through inhibitory A1
and facilitatory A2A receptors. Although both adenosine receptor-mediated inhibition and …

Evidence for functionally important adenosine A2a receptors in the rat hippocampus

RA Cunha, B Johansson, I van der Ploeg, AM Sebastia… - Brain research, 1994 - Elsevier
Adenosine A 2a receptors are not confined to dopamine-rich areas of the brain, since
thermocycling analysis shows that adenosine A 2a receptor mRNA is expressed also in the …

Subcellular localization of adenosine A1 receptors in nerve terminals and synapses of the rat hippocampus

N Rebola, PC Pinheiro, CR Oliveira, JO Malva… - Brain research, 2003 - Elsevier
Adenosine is a neuromodulator in the CNS that mainly acts through pre-and postsynaptic A1
receptors to inhibit the release of excitatory neurotransmitters and NMDA receptor function …

Activation of hippocampal adenosine A3 receptors produces a desensitization of A1 receptor-mediated responses in rat hippocampus

TV Dunwiddie, L Diao, HO Kim, JL Jiang… - Journal of …, 1997 - Soc Neuroscience
The adenosine A3 receptor is expressed in brain, but the consequences of activation of this
receptor on electrophysiological activity are unknown. We have characterized the actions of …

Cellular localization of adenosine A1 receptors in rat forebrain: immunohistochemical analysis using adenosine A1 receptor‐specific monoclonal antibody

T Ochiishi, L Chen, A Yukawa, Y Saitoh… - Journal of …, 1999 - Wiley Online Library
Monoclonal antibodies were generated against the adenosine A1 receptor (A1R) purified
from rat brain. In immunoblot analyses of purified or partially purified A1R preparations from …

Interaction between adenosine A1 and A2 receptor-mediated responses in the rat hippocampus in vitro

EM O'Kane, TW Stone - European journal of pharmacology, 1998 - Elsevier
Previous work has been carried out on the effects of adenosine on transmitter release and
on the excitability of postsynaptic neurones, but little is known about the effects of adenosine …

Binding of the prototypical adenosine A2A receptor agonist CGS 21680 to the cerebral cortex of adenosine A1 and A2A receptor knockout mice

LV Lopes, L Halldner, N Rebola… - British journal of …, 2004 - Wiley Online Library
2‐p‐(2‐carboxyethylphenethylamino‐5′‐ethylcarboxamidoadenosine)(CGS 21680) is
considered the reference compound to study adenosine A2A receptors. However, CGS …

Immunohistochemical detection of A1 adenosine receptors in rat brain with emphasis on localization in the hippocampal formation, cerebral cortex, cerebellum, and …

SA Rivkees, SL Price, FC Zhou - Brain research, 1995 - Elsevier
Polyclonal antisera were generated against two identical regions of rat and human A1
adenosine receptors using synthetic multiple-antigenic-peptides as immunogens. Western …

High level of adenosine A1 receptor-like immunoreactivity in the CA2/CA3a region of the adult rat hippocampus

T Ochiishi, Y Saitoh, A Yukawa, M Saji, Y Ren, T Shirao… - Neuroscience, 1999 - Elsevier
We describe the immunocytochemical distribution of adenosine A1 receptors in the rat
hippocampus. Adenosine A1 receptor-like immunoreactivity was seen on the cell soma and …