The regional distribution of adenosine A 2 receptors in the rat brain was determined using
the A 2-selective agonist ligand [3 H](2-p-carboxyethyl) phenylamino)-5′-N …

Adenosine either inhibits or facilitates synaptic transmission through A1 or A2A receptors,
respectively. Since A2A receptor density increases in the limbic cortex of aged (24 mo) …

Evaluation of adenosine A2 receptor function in the mammalian CNS has been impeded by
the lack ofhighly selective A2 receptor agonists. The present investigations describe the …

Adenosine tonically inhibits synaptic transmission through actions at A1 receptors. It also
facilitates synaptic transmission, but it is unclear if this facilitation results from pre-and/or …

Adenosine A2 receptors were labeled and visualized by autoradiography in tissue sections
of the human brain using the A2-selective agonist ligand [3 H](2-p-(2-car☐ yethyl) …

Electrophysiological recordings in rat brain slices have been used to study the actions of
adenosine on striatal neurons and striatal excitatory amino acid neurotransmission …

We isolated and characterized a 4.8‐kb 5′ flanking region of the rat A2A adenosine
receptor (A2A‐R) gene in the present study. Promoter activity was observed with this DNA …

ABSTRACT A1 adenosine receptors in the rat prepinform cortex play an important role in the
inhibition of bicuculline methiodide-induced convulsions. In the present study we evaluated …

Adenosine inhibits excitatory neurons widely in the brain through adenosine A1 receptor,
but activation of adenosine A2A receptor (A2AR) has an opposite effect promoting discharge …

In the hippocampus, the neuromodulatory role of adenosine depends on a balance between
inhibitory A1 responses and facilitatory A2A responses. Since the presynaptic effects of …