A cascade signaling network between artificial cells switching activity of synthetic transmembrane channels
Q Yang, Z Guo, H Liu, R Peng, L Xu, C Bi… - Journal of the …, 2020 - ACS Publications
Cell–cell communication plays a vital role in biological activities; in particular, membrane–
protein interactions are profoundly significant. In order to explore the underlying mechanism …
protein interactions are profoundly significant. In order to explore the underlying mechanism …
Controllable synthetic ion channels
JY Chen, JL Hou - Organic Chemistry Frontiers, 2018 - pubs.rsc.org
Natural channel proteins are complex in structure and marvelous in function. Chemists have
constructed a variety of simple synthetic structures with the goal of mimicking the function of …
constructed a variety of simple synthetic structures with the goal of mimicking the function of …
Engineered ion channels as emerging tools for chemical biology
Over the last 25 years, researchers have developed exogenously expressed, genetically
engineered, semi-synthetic, and entirely synthetic ion channels. These structures have …
engineered, semi-synthetic, and entirely synthetic ion channels. These structures have …
Synthetic ion channels in bilayer membranes
TM Fyles - Chemical Society Reviews, 2007 - pubs.rsc.org
Natural ion channels are large protein complexes that regulate key functions of cells.
Supramolecular chemists have been able to take hints from Nature to design and prepare …
Supramolecular chemists have been able to take hints from Nature to design and prepare …
Building a synthetic mechanosensitive signaling pathway in compartmentalized artificial cells
JW Hindley, DG Zheleva, Y Elani… - Proceedings of the …, 2019 - National Acad Sciences
To date, reconstitution of one of the fundamental methods of cell communication, the
signaling pathway, has been unaddressed in the bottom-up construction of artificial cells …
signaling pathway, has been unaddressed in the bottom-up construction of artificial cells …
Signal-triggered transmembrane ion transport through synthetic channels
RS Hector, MS Gin - Supramolecular Chemistry, 2005 - Taylor & Francis
This review discusses recent advances in mimicry of transmembrane ion channel proteins
using artificial systems. While modified protein channels and surface-functionalized …
using artificial systems. While modified protein channels and surface-functionalized …
Artificial signal transduction across membranes
S Vanuytsel, J Carniello, MI Wallace - ChemBioChem, 2019 - Wiley Online Library
A key conundrum in the construction of an artificial cell is to simultaneously maintain a
robust physical barrier to the external environment, while also providing efficient exchange …
robust physical barrier to the external environment, while also providing efficient exchange …
Engineering receptor-mediated transmembrane signaling in artificial and living cells
K Shi, C Song, Y Wang, R Chandrawati… - Communications …, 2023 - nature.com
Living cells possess a variety of transmembrane signaling systems that receive chemical
and physical cues from the environment and transduce this information into an intracellular …
and physical cues from the environment and transduce this information into an intracellular …
Transmembrane signaling by a synthetic receptor in artificial cells
AB Søgaard, AB Pedersen, KB Løvschall… - Nature …, 2023 - nature.com
Signal transduction across biological membranes is among the most important evolutionary
achievements. Herein, for the design of artificial cells, we engineer fully synthetic receptors …
achievements. Herein, for the design of artificial cells, we engineer fully synthetic receptors …
DNA‐Based Artificial Receptors as Transmembrane Signal Transduction Systems for Protocellular Communication
H Chen, W Xu, H Shi, Y Qiao, X He, J Zheng… - Angewandte …, 2023 - Wiley Online Library
The ability to reproduce signal transduction and cellular communication in artificial cell
systems is significant in synthetic protobiology. Here, we describe an artificial …
systems is significant in synthetic protobiology. Here, we describe an artificial …