IL-33 exacerbates antigen-induced arthritis by activating mast cells
D Xu, HR Jiang, P Kewin, Y Li, R Mu… - Proceedings of the …, 2008 - National Acad Sciences
IL-33, a cytokine of the IL-1 family, is closely associated with type II T cell responses. Here,
we report an unexpected proinflammatory role of IL-33 in inflammatory arthritis. IL-33 was …
we report an unexpected proinflammatory role of IL-33 in inflammatory arthritis. IL-33 was …
Emerging functions of IL-33 in homeostasis and immunity
GK Dwyer, LM D'Cruz… - Annual review of …, 2022 - annualreviews.org
Our understanding of the functions of the IL-1 superfamily cytokine and damage-associated
molecular pattern IL-33 continues to evolve with our understanding of homeostasis and …
molecular pattern IL-33 continues to evolve with our understanding of homeostasis and …
IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines
J Schmitz, A Owyang, E Oldham, Y Song, E Murphy… - Immunity, 2005 - cell.com
Cytokines of the interleukin-1 (IL-1) family, such as IL-1α/β and IL-18, have important
functions in host defense, immune regulation, and inflammation. Insight into their biological …
functions in host defense, immune regulation, and inflammation. Insight into their biological …
IL-33 in rheumatic diseases
Y Dong, J Zhong, L Dong - Frontiers in Medicine, 2021 - frontiersin.org
Interleukin-33 (IL-33) is a nuclear factor mainly expressed in barrier epithelium, endothelial
cells, and fibroblast reticular cells. Some inflammatory cells also express IL-33 under certain …
cells, and fibroblast reticular cells. Some inflammatory cells also express IL-33 under certain …
Pleiotropic Effects of IL-33 on CD4+ T Cell Differentiation and Effector Functions
F Alvarez, JH Fritz, CA Piccirillo - Frontiers in immunology, 2019 - frontiersin.org
IL-33, a member of the IL-1 family of cytokines, was originally described in 2005 as a
promoter of type 2 immune responses. However, recent evidence reveals a more complex …
promoter of type 2 immune responses. However, recent evidence reveals a more complex …
IL33: roles in allergic inflammation and therapeutic perspectives
Interleukin (IL)-33 belongs to IL-1 cytokine family which is constitutively produced from the
structural and lining cells including fibroblasts, endothelial cells, and epithelial cells of skin …
structural and lining cells including fibroblasts, endothelial cells, and epithelial cells of skin …
Full-length IL-33 promotes inflammation but not Th2 response in vivo in an ST2-independent fashion
Expression of IL-33 is elevated in patients with pulmonary diseases, and full-length (not
proteolytically processed) IL-33 is the predominant form in the lungs in health and disease …
proteolytically processed) IL-33 is the predominant form in the lungs in health and disease …
IL-1 receptor accessory protein and ST2 comprise the IL-33 receptor complex
AA Chackerian, ER Oldham, EE Murphy… - The Journal of …, 2007 - journals.aai.org
Abstract IL-33 (IL-1F11) is a recently described member of the IL-1 family of cytokines that
stimulates the generation of cells, cytokines, and Igs characteristic of a type 2 immune …
stimulates the generation of cells, cytokines, and Igs characteristic of a type 2 immune …
Therapeutic strategies for targeting IL-33/ST2 signalling for the treatment of inflammatory diseases
Abstract Interleukin (IL)-33, a member of the IL-1 family of cytokines, is involved in innate
and adaptive immune responses via interaction with its receptor, ST2. Activation of ST2 …
and adaptive immune responses via interaction with its receptor, ST2. Activation of ST2 …
Interleukin (IL)-33 induces the release of pro-inflammatory mediators by mast cells
IL-33 (or IL-1F11) was recently identified as a ligand for the previously orphaned IL-1 family
receptor T1/ST2. Previous studies have established that IL-33 and T1/ST2 exert key …
receptor T1/ST2. Previous studies have established that IL-33 and T1/ST2 exert key …