Abstract Interleukin-33 (IL-33) is a member of the IL-1 family and plays an ambivalent role in
autoimmune diseases. IL-33 signals via the ST2 receptor and drives cytokine production in …

Interleukin-33 (IL-33) is a novel member of the IL-1 cytokine family. It has been shown to
elicit a Th2-like cytokine response in immunocompetent cells through binding and activation …

IL-33 (previously known as NF from high endothelial venules) is an IL-1 family cytokine that
signals through the ST2 receptor and drives cytokine production in mast cells, basophils …

Interleukin (IL)-33, a member of the IL-1 family of cytokines, is produced when epithelial and
endothelial cells are exposed to stimuli. Hematopoietic cells such as macrophages also …

Cytokines are key mediators of the immune system, and few have been more thoroughly
studied than those of the IL-1 family. IL-1α and IL-1β are the founding members and now …

Abstract Interleukin-33 (IL-33) is the most attractive novel cytokine identified as an IL-1 family
member. IL-33 was first named NF-HEV (nuclear factor from high endothelial venules), as it …

Abstract In mice, interleukin-18 (IL-18) regulates Th1-or Th2-type immune responses
depending on the cytokine environment and effector cells involved, and the ST2-ligand, IL …

Abstract Interleukin-33 (IL-33), a member of the IL-1 family of cytokines, binds to its plasma
membrane receptor, heterodimeric complex consisted of membrane-bound ST2L and IL-1R …

Highlights•IL-33 is a crucial activator of ILC2s in innate immunity and allergic
inflammation.•The gene encoding IL-33 is a major susceptibility locus for human asthma.•IL …

In addition to IL-1 and IL-18, IL-33 was recently identified as a member of the IL-1 cytokine
family. rIL-33 can promote production of Th2-type cytokines by Th2 cells and mast cells in …