Coating techniques and release kinetics of drug-eluting stents

M Livingston, A Tan - Journal of medical devices, 2016 - asmedigitalcollection.asme.org
Implantation of drug-eluting stents (DESs) via percutaneous coronary intervention is the
most popular treatment option to restore blood flow to occluded vasculature. The many …

Mechanisms of controlled drug release from drug-eluting stents

G Acharya, K Park - Advanced drug delivery reviews, 2006 - Elsevier
The clinical importance of drug-eluting stents (DESs) has been demonstrated by their
unparalleled success in preventing restenosis after stenting procedures. The magnitude of …

[HTML][HTML] Enhanced drug delivery capabilities from stents coated with absorbable polymer and crystalline drug

WC Carlyle, JB McClain, AR Tzafriri, L Bailey… - Journal of controlled …, 2012 - Elsevier
Current drug eluting stent (DES) technology is not optimized with regard to the
pharmacokinetics of drug delivery. A novel, absorbable-coating sirolimus-eluting stent (AC …

[PDF][PDF] New generations of drug-eluting stents-A brief review

A Ernst, J Bulum - EMJ Int Cardiol, 2014 - emjreviews.com
This review focuses on describing new generations of drug-eluting stents (DES) based on
the use of novel stent platforms, coatings, and carrier systems, developed to enhance DES …

Controlled slow-release drug-eluting stents for the prevention of coronary restenosis: recent progress and future prospects

T Hu, J Yang, K Cui, Q Rao, T Yin, L Tan… - … applied materials & …, 2015 - ACS Publications
Drug-eluting stents (DES) have become more widely used by cardiologists than bare metal
stents (BMS) because of their better ability to control restenosis. However, recognized …

Drug-eluting stents: A multidisciplinary success story

HM Burt, WL Hunter - Advanced drug delivery reviews, 2006 - Elsevier
Coronary stenting is the most common form of interventional treatment for symptomatic
coronary artery disease. In-stent restenosis following bare metal stent (BMS) placement is …

Drug-eluting stents in preclinical studies: recommended evaluation from a consensus group

RS Schwartz, ER Edelman, A Carter, N Chronos… - Circulation, 2002 - Am Heart Assoc
protein binding, and molecular weight and charge. For example, the release of protein-
binding drugs should be examined in protein-containing solutions. Elution features may …

Evaluation of the in vitro drug release from resorbable biocompatible coatings for vascular stents

T Sharkawi, D Leyni-Barbaz, N Chikh… - Journal of bioactive …, 2005 - journals.sagepub.com
The objective of this work was to prepare a biocompatible and degradable polymer coating
for vascular stents that would release a restenosis inhibitor for a sustained period of time. To …

Evaluation of drug‐eluting stents' coating durability—Clinical and regulatory implications

Y Levy, D Mandler, J Weinberger… - Journal of Biomedical …, 2009 - Wiley Online Library
Drug‐eluting stents (DES) revolutionized cardiovascular treatment by virtually eliminating in‐
stent restanosis. However, in the past 3 years the US Food and Drug Administration and …

New drug-eluting stents: an overview on biodegradable and polymer-free next-generation stent systems

A Abizaid, JR Costa Jr - Circulation: Cardiovascular Interventions, 2010 - Am Heart Assoc
Drug-eluting stents (DES) were primarily conceived to re-duce in-stent neointimal formation
and therefore minimize the occurrence of restenosis, the major drawback of percutaneous …