The presence of an adequate blood supply is a critical factor in recovery from traumatic
injuries. We have examined whether the revascularization of the injured tissues is as crucial …

Lesions of the CNS induce a complex cascade of tissue reactions. The purpose of this study
was to determine the response of the vasculature to partial spinal cord transection. Adult rat …

✓ This study shows that spinal cord pathology secondary to acute trauma in monkeys
evolves with stepwise sequential changes. The acute damage is more central than …

Contusion injuries of the rat thoracic spinal cord were made using a standardized device
developed for the Multicenter Animal Spinal Cord Injury Study (MASCIS). Lesions of different …

✓ Vascular injury plays an important role in the primary and secondary injury mechanisms
that cause damage to the acutely traumatized spinal cord. To understand the …

Tissue destruction at the primary site of a spinal cord injury leads to persistent necrosis that
progressively enlarges the lesion. Steroids attenuate this necrotizing process and promote …

To date, there are no reports of growth of significant numbers of axons into or across a lesion
of the mammalian spinal cord. However, recent studies showing that CNS axons will grow …

✓ The pathology of spinal cord injury has been studied in 34 rabbits and 5 dogs with
attention focused on the condition of the microvasculature during the evolution of neuronal …

Blood vessels identified by laminin staining were studied in uninjured spinal cord and at 2,
4, 7, and 14 days following a moderate contusion (weight drop) injury. At 2 days after injury …

Progressive tissue necrosis is a process unique to the injured mammalian spinal cord which
often leads to gradually increasing cavitation and enlargement of the lesion. To evaluate the …