Innate immune cells in the adipose tissue

KJ Chung, M Nati, T Chavakis… - Reviews in Endocrine and …, 2018 - Springer
Immune cells are present in the adipose tissue (AT) and regulate its function. Under lean
conditions, immune cells predominantly of type 2 immunity, including eosinophils, M2-like …

The role of adipose tissue immune cells in obesity and low-grade inflammation

M Mraz, M Haluzik - Journal of Endocrinology, 2014 - joe.bioscientifica.com
Adipose tissue (AT) lies at the crossroad of nutrition, metabolism, and immunity; AT
inflammation was proposed as a central mechanism connecting obesity with its metabolic …

[HTML][HTML] Innate immune cells in the adipose tissue in health and metabolic disease

Z Michailidou, M Gomez-Salazar… - Journal of innate immunity, 2022 - karger.com
Metabolic disorders, such as obesity, type 2 diabetes mellitus, and nonalcoholic fatty liver
disease, are characterized by chronic low-grade tissue and systemic inflammation. During …

Adipocytes, innate immunity and obesity: A mini-review

AM Blaszczak, A Jalilvand, WA Hsueh - Frontiers in immunology, 2021 - frontiersin.org
The role of adipose tissue (AT) inflammation in obesity and its multiple related-complications
is a rapidly expanding area of scientific interest. Within the last 30 years, the role of the …

The role of innate immune cells in obese adipose tissue inflammation and development of insulin resistance

J Chmelar, KJ Chung… - Thrombosis and …, 2013 - thieme-connect.com
Obesity is characterised by a chronic state of low-grade inflammation in different tissues
including the vasculature. There is a causal link between adipose tissue (AT) inflammation …

[HTML][HTML] Crosstalk between adipocytes and immune cells in adipose tissue inflammation and metabolic dysregulation in obesity

JY Huh, YJ Park, M Ham, JB Kim - Molecules and cells, 2014 - Elsevier
Recent findings, notably on adipokines and adipose tissue inflammation, have revised the
concept of adipose tissues being a mere storage depot for body energy. Instead, adipose …

The immune system in obesity: developing paradigms amidst inconvenient truths

M Agrawal, PA Kern, BS Nikolajczyk - Current diabetes reports, 2017 - Springer
Abstract Purpose of Review Adipose tissue (AT) houses both innate and adaptive immune
systems that are crucial for preserving AT function and metabolic homeostasis. In this …

Orchestration of the Adipose Tissue Immune Landscape by Adipocytes

D Bradley, T Deng, D Shantaram… - Annual review of …, 2024 - annualreviews.org
Obesity is epidemic and of great concern because of its comorbid and costly inflammatory-
driven complications. Extensive investigations in mice have elucidated highly coordinated …

The macrophage switch in obesity development

A Castoldi, C Naffah de Souza, NOS Câmara… - Frontiers in …, 2016 - frontiersin.org
Immune cell infiltration in (white) adipose tissue (AT) during obesity is associated with the
development of insulin resistance. In AT, the main population of leukocytes are …

Human primary adipocytes exhibit immune cell function: adipocytes prime inflammation independent of macrophages

K Meijer, M de Vries, S Al-Lahham, M Bruinenberg… - PloS one, 2011 - journals.plos.org
Background Obesity promotes inflammation in adipose tissue (AT) and this is implicated in
pathophysiological complications such as insulin resistance, type 2 diabetes and …