The VAChT/ChAT “cholinergic gene locus”: new aspects of genetic and vesicular regulation of cholinergic function

JD Erickson, E Weihe, MKM Schäfer, E Neale… - Progress in brain …, 1996 - Elsevier
Publisher Summary This chapter focuses on the structural features of vesicular acetylcholine
transporter (VAChT) deduced from its primary sequence, which give insight into its …

Expression of the putative vesicular acetylcholine transporter in rat brain and localization in cholinergic synaptic vesicles

ML Gilmor, NR Nash, A Roghani… - Journal of …, 1996 - Soc Neuroscience
A cholinergic locus has recently been identified consisting of a unique mammalian genomic
arrangement containing the genes for choline acetyltransferase (ChAT) and a putative …

Differences in the developmental expression of the vesicular acetylcholine transporter and choline acetyltransferase in the rat brain

T Hollera, B Berse, JM Cermak, MF Diebler… - Neuroscience …, 1996 - Elsevier
The neurotransmitter acetylcholine (ACh) is synthesized by the enzyme choline
acetyltransferase (ChAT) and then transported into synaptic vesicles by the vesicular …

The cholinergic gene locus

LE Eiden - Journal of neurochemistry, 1998 - Wiley Online Library
Messenger RNAs and the cognate gene (s) encoding choline acetyltransferase (ChAT) and
the vesicular acetylcholine transporter (VAChT) have been cloned from mammals and …

Distribution of the vesicular acetylcholine transporter (VAChT) in the central and peripheral nervous systems of the rat

MKH Schäfer, E Weihe, H Varoqui, LE Eiden… - Journal of Molecular …, 1994 - Springer
Expression of the acetylcholine biosynthetic enzyme choline acetyltransferase (ChAT), the
vesicular acetylcholine transporter (VAChT), and the high-affinity plasma membrane choline …

Molecular characterization of the mouse vesicular acetylcholine transporter gene

JM Naciff, H Misawa, JR Dedman - Neuroreport, 1997 - journals.lww.com
THE organization of the mouse choline acetyltransferase (ChAT) gene has been previously
analyzed. Here we show that the first intron of the mouse ChAT gene contains an …

Identification and transgenic analysis of a murine promoter that targets cholinergic neuron expression

JM Naciff, MM Behbehani, H Misawa… - Journal of …, 1999 - Wiley Online Library
Choline acetyltransferase (ChAT) is a specific phenotypic marker of cholinergic neurons.
Previous reports showed that different upstream regions of the ChAT gene are necessary for …

Coregulation of two embedded gene products, choline acetyltransferase and the vesicular acetylcholine transporter

S Berrard, H Varoqui, R Cervini, M Israël… - Journal of …, 1995 - Wiley Online Library
The gene encoding the vesicular acetylcholine transporter (VAChT) has recently been
localized within the first intron of the gene encoding choline acetyltransferase (ChAT) and is …

Molecular cloning of a putative vesicular transporter for acetylcholine.

A Roghani, J Feldman, SA Kohan… - Proceedings of the …, 1994 - National Acad Sciences
Classical neurotransmitters such as acetylcholine (ACh) require transport into synaptic
vesicles for regulated exocytotic release. The Caenorhabditis elegans gene unc-17 encodes …

Human and monkey cholinergic neurons visualized in paraffin-embedded tissues by immunoreactivity for VAChT, the vesicular acetylcholine transporter

MKH Schäfer, E Weihe, JD Erickson… - Journal of Molecular …, 1995 - Springer
The predicted C-terminal dodecapeptide of the human vesicular acetylcholine transporter
(VAChT), deduced from the unique open reading frame of the recently cloned human …