[HTML][HTML] eSNaPD: a versatile, web-based bioinformatics platform for surveying and mining natural product biosynthetic diversity from metagenomes

BVB Reddy, A Milshteyn, Z Charlop-Powers… - Chemistry & biology, 2014 - cell.com
Summary Environmental Surveyor of Natural Product Diversity (eSNaPD) is a web-based
bioinformatics and data aggregation platform that aids in the discovery of gene clusters …

Culture-independent discovery of natural products from soil metagenomes

M Katz, BM Hover, SF Brady - Journal of Industrial Microbiology …, 2016 - academic.oup.com
Bacterial natural products have proven to be invaluable starting points in the development of
many currently used therapeutic agents. Unfortunately, traditional culture-based methods for …

The confluence of big data and evolutionary genome mining for the discovery of natural products

MG Chevrette, A Gavrilidou, S Mantri… - Natural product …, 2021 - pubs.rsc.org
This review covers literature between 2003–2021 The development and application of
genome mining tools has given rise to ever-growing genetic and chemical databases and …

A computational framework to explore large-scale biosynthetic diversity

JC Navarro-Muñoz, N Selem-Mojica… - Nature chemical …, 2020 - nature.com
Genome mining has become a key technology to exploit natural product diversity. Although
initially performed on a single-genome basis, the process is now being scaled up to mine …

Metabolomics and genomics in natural products research: complementary tools for targeting new chemical entities

LK Caesar, R Montaser, NP Keller… - Natural product reports, 2021 - pubs.rsc.org
Covering: 2010 to 2021 Organisms in nature have evolved into proficient synthetic chemists,
utilizing specialized enzymatic machinery to biosynthesize an inspiring diversity of …

Integrated metabolomic–genomic workflows accelerate microbial natural product discovery

NE Avalon, AE Murray, BJ Baker - Analytical chemistry, 2022 - ACS Publications
The pairing of analytical chemistry with genomic techniques represents a new wave in
natural product chemistry. With an increase in the availability of sequencing and assembly of …

[HTML][HTML] The natural product domain seeker NaPDoS: a phylogeny based bioinformatic tool to classify secondary metabolite gene diversity

N Ziemert, S Podell, K Penn, JH Badger, E Allen… - PloS one, 2012 - journals.plos.org
New bioinformatic tools are needed to analyze the growing volume of DNA sequence data.
This is especially true in the case of secondary metabolite biosynthesis, where the highly …

Microbial natural product databases: moving forward in the multi-omics era

JA Van Santen, SA Kautsar, MH Medema… - Natural Product …, 2021 - pubs.rsc.org
Covering: 2010–2020 The digital revolution is driving significant changes in how people
store, distribute, and use information. With the advent of new technologies around linked …

The natural products atlas: an open access knowledge base for microbial natural products discovery

JA Van Santen, G Jacob, AL Singh, V Aniebok… - ACS central …, 2019 - ACS Publications
Despite rapid evolution in the area of microbial natural products chemistry, there is currently
no open access database containing all microbially produced natural product structures …

Mining for microbial gems: integrating proteomics in the postgenomic natural product discovery pipeline

C Du, GP van Wezel - Proteomics, 2018 - Wiley Online Library
Natural products (NPs) are a major source of compounds for medical, agricultural, and
biotechnological industries. Many of these compounds are of microbial origin, and, in …