Beta3-adrenoreceptors (B3AR) are traditionally known as metabolic receptors in adipose
tissue, but came into focus in the cardiovascular field after our demonstration of their …

The third isotype of beta-adrenoreceptors (β3-AR) has recently come (back) into focus after
the observation of its expression in white and beige human adipocytes and its implication in …

While crucial for the acute physiologic response to stress, the adrenergic system may
become maladaptive upon prolonged stimulation in the course of development of heart …

Catecholamines released by the orthosympathetic system play a major role in the short-and
long-term regulation of cardiovascular function. Beta1-and beta2-adrenoreceptors (ARs) …

As heart failure (HF) is a growing public health problem worldwide, rapid therapeutic
development is required to improve HF management. Decreased myocardial contractility in …

Overstimulation of the orthosympathetic system leads to cardiovascular cell and tissue
damage through prolonged activation of β-1-2 adrenergic receptors (BARs). The more …

Catecholamines play a key role in the regulation of cardiovascular function, classically
through ß 1/2-adrenoreceptors (AR) activation. After ß 3-AR cloning in the late 1980s …

The sympathetic nervous system is central for the neurohumoral regulation of the
cardiovascular system and is largely involved in many cardiovascular diseases affecting …

Aims The abundance of beta 3‐adrenergic receptors (β3‐ARs) is upregulated in diseased
human myocardium. We previously showed that cardiac‐specific expression of β3‐AR …

Background—Transgenic cardiac β2-adrenergic receptor (AR) overexpression has resulted
in enhanced signaling and cardiac function in mice, whereas relatively low levels of …