Three independent pathways of nuclear import have so far been identified in yeast, each
mediated by cognate nuclear transport factors, or karyopherins. Here we have characterized …

We sublocalized the yeast nucleoporin Nup82 to the cytoplasmic side of the nuclear pore
complex (NPC) by immunoelectron microscopy. Moreover, by in vitro binding assays we …

The nuclear import of proteins bearing a basic nuclear localization signal (NLS) is
dependent on karyopherin α/importin α, which acts as the NLS receptor, and karyopherin …

Fully processed mRNAs are exported to the cytoplasm where they direct protein synthesis. A
general feature of mRNA export is that it is an active, receptor-mediated process. The mRNA …

Nuclear import of classical nuclear localization sequence-bearing proteins is mediated by
karyopherin α/β1 heterodimers. A second nuclear import pathway, mediated by karyopherin …

One of the most profound differences between prokaryotes and eukaryotes is that only the
latter segregate RNA synthesis and protein synthesis into distinct cellular compartments, ie …

MTR10, previously shown to be involved in mRNA export, was found in a synthetic lethal
relationship with nucleoporin NUP85. Green fluorescent protein (GFP)‐tagged Mtr10p …

ABSTRACT Human transportin1 (hTRN1) is the nuclear import receptor for a group of pre-
mRNA/mRNA-binding proteins (heterogeneous nuclear ribonucleoproteins [hnRNP]) …

Characterization of the interactions between soluble factors required for nuclear transport is
key to understanding the process of nuclear trafficking. Using a synthetic lethal screen with …

In the past two years, our knowledge concerning the mechanisms of nucleocytoplasmic
transport through the nuclear pore complex (NPC) has considerably expanded. The …