Alcoholic liver disease: mechanisms of injury and targeted treatment

A Louvet, P Mathurin - Nature reviews Gastroenterology & hepatology, 2015 - nature.com
Alcoholic liver disease (ALD) is a complex process that includes a wide spectrum of hepatic
lesions, from steatosis to cirrhosis. Cell injury, inflammation, oxidative stress, regeneration …

Pathogenesis of alcohol-associated liver disease

NA Osna, K Rasineni, M Ganesan… - Journal of Clinical and …, 2022 - Elsevier
Excessive alcohol consumption is a global healthcare problem with enormous social,
economic, and clinical consequences. While chronic, heavy alcohol consumption causes …

Alcoholic liver disease: pathogenesis, management, and novel targets for therapy

ES Orman, G Odena, R Bataller - Journal of gastroenterology …, 2013 - Wiley Online Library
Alcohol use is a leading cause of preventable morbidity and mortality worldwide, with much
of its negative impact as the result of alcoholic liver disease (ALD). ALD is a broad term that …

[PDF][PDF] Alcoholic hepatitis: translational approaches to develop targeted therapies

P Mandrekar, R Bataller, H Tsukamoto, B Gao - Hepatology, 2016 - Wiley Online Library
Alcoholic liver disease is a leading cause of liver‐related mortality worldwide. In contrast to
recent advances in therapeutic strategies for patients with viral hepatitis, there is a significant …

Alcoholic liver disease–pathophysiological aspects and risk factors

A Gramenzi, F Caputo, M Biselli, F Kuria… - Alimentary …, 2006 - Wiley Online Library
Background Alcoholic liver disease has a known aetiology but a complex and incompletely
known pathogenesis. It is an extremely common disease with significant morbidity and …

Recent advances in understanding of pathogenesis of alcohol-associated liver disease

X Wu, X Fan, T Miyata, A Kim… - Annual Review of …, 2023 - annualreviews.org
Alcohol-associated liver disease (ALD) is one of the major diseases arising from chronic
alcohol consumption and is one of the most common causes of liver-related morbidity and …

Alcoholic liver disease: pathogenesis and new targets for therapy

J Altamirano, R Bataller - Nature reviews Gastroenterology & …, 2011 - nature.com
Alcoholic liver disease (ALD) is a major cause of morbidity and mortality worldwide. The
spectrum of disease ranges from fatty liver to hepatic inflammation, necrosis, progressive …

Alcoholic liver disease: new insights into mechanisms and preventative strategies

S Stewart, D Jones, CP Day - Trends in molecular medicine, 2001 - cell.com
Alcoholic liver disease has a known aetiology but a complex pathogenesis. It is an extremely
common disease with a high mortality, but the reason why only a relatively small proportion …

Alcoholic liver disease: pathogenesis and new therapeutic targets

B Gao, R Bataller - Gastroenterology, 2011 - Elsevier
Alcoholic liver disease (ALD) is a major cause of chronic liver disease worldwide and can
lead to fibrosis and cirrhosis. The latest surveillance report published by the National …

Alcoholic liver disease: alcohol metabolism, cascade of molecular mechanisms, cellular targets, and clinical aspects

R Teschke - Biomedicines, 2018 - mdpi.com
Alcoholic liver disease is the result of cascade events, which clinically first lead to alcoholic
fatty liver, and then mostly via alcoholic steatohepatitis or alcoholic hepatitis potentially to …