Immobilized metal affinity chromatography (IMAC) is a powerful method in phosphopeptide
enrichment. However, the achievement of highly specific enrichment and sensitive detection …

Highly selective and efficient enrichment of trace phosphorylated proteins or peptides from
complex biological samples is of profound significance for the discovery of disease …

Immobilized metal ion affinity chromatography (IMAC) is widely used for phosphopeptide
enrichment. However, the robustness, efficiency, and specificity of this technique in large …

A new type of IMAC material, with ATP as the chelating ligand, was synthesized and applied
to capture phosphopeptides. For the first time, the approach for phosphopeptide enrichment …

Selective capture of mono-, multi-or global phosphopeptides is significant for the in-depth
study of protein kinase or phosphatase signal transduction pathways. However, this study is …

Highly effective enrichment of phosphorylated biomolecules is vital for an in depth and
comprehensive phosphoproteome analysis. Among affinity materials, materials based on …

Large scale characterization of phosphoproteins requires highly specific methods for
purification of phosphopeptides because of the low abundance of phosphoproteins and …

Phosphorylation is a crucial post-translational modification, which plays pivotal roles in
various biological processes. Analysis of phosphopeptides by mass spectrometry (MS) is …

Reversible phosphorylation of proteins is one of the most important post-translational
modifications, while the detection of phosphopeptides is difficult due to their low abundance …

A marked decrease in the saturation magnetization by the formation of functional shells
around the magnetic core is an important disadvantage of magnetic core-shell …