Skeletal cells control the initiation of mineralization in vivo and determine the selective
distribution pattern of mineralization by releasing calcification-initiating, submicroscopic …

In normal healthy individuals, mineral formation is restricted to specialized tissues which
form the skeleton and the dentition. Within these tissues, mineral formation is tightly …

Matrix vesicles have a critical role in the initiation of mineral deposition in skeletal tissues,
but the ways in which they exert this key function remain poorly understood. This issue is …

Matrix vesicles (MVs) are extracellular, 100 nM in diameter, membrane-invested particles
selectively located at sites of initial calcification in cartilage, bone, and predentin. The first …

The factors that drive mineralization of matrix vesicles (MV) have proven difficult to elucidate;
in the present studies, various detergent, chemical, and enzyme treatments were used to …

BACKGROUND: Matrix vesicles have been implicated in the mineralization of calcified
cartilage, bone and dentin for more than 40 years. During this period, their exact role, if any …

Abstract Background Matrix vesicles (MVs) are released from hypertrophic chondrocytes
and from mature osteoblasts, the cells responsible for endochondral and membranous …

This review aims to propose a more consistent interpretation of the concept of matrix vesicle
mineralization, and includes current views on biomineralization in general. We first focused …

Numerous studies have documented that matrix vesicles are unique extracellular membrane-
bound microparticles that serve as initial sites for mineral formation in the growth plate and …

Matrix vesicles are widely regarded as the initial site of calcification in epiphyseal growth
plate cartilage, in growing bone and in predentin. This opinion has recently been challenged …