Background. Family history of prostate cancer is a risk factor for prostate cancer occurrence.
Differently from other neoplasms no major predisposing gene has been identified. Material …

In many developed countries, prostate cancer is the most frequently diagnosed malignancy
in men. The extent to which the marked racial/ethnic difference in its incidence rate is …

Current epidemiologic and genetic data suggest the hypothetical paradigm that prostate
cancer occurs in three forms: sporadic, familial, and hereditary (Figure 1). Sporadic cases …

Considerable evidence demonstrates that genetic factors are important in the development
and aggressiveness of prostate cancer. To identify genetic variants that predispose to …

Prostate carcinoma is the most common cancer in men with more than 100,000 new cases
of this disease occurring in the United States in 1990 [1]. More than 30,000 men die of …

Since the first report of a genome-wide scan for hereditary prostate cancer (HPCA
hereinafter) in 1996, several publications have presented data implicating various …

Hereditary prostate cancer, a newly described variant of prostate cancer, is distinguished by
early age at onset and autosomal dominant inheritance within families. 1 We review the …

Despite the substantial clinical importance of prostate cancer, the molecular mechanisms
underlying the development and progression of the disease are poorly understood. The aim …

It has been suggested that positive family history constitutes a risk factor for the development
of prostate cancer. Familial clustering of prostate cancer might suggest that genetic factors …

Molecular Genetics and Epidemiology of Prostate Carcinoma | Endocrine Reviews | Oxford
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