OBJECTIVES: To conduct genetic linkage analysis in order to localize predisposition genes
for hereditary prostate cancer (CaP), as various epidemiological studies have demonstrated …

The article discusses the genetic components in determining the genetic factors for prostate
cancer risk. In Mendelian model, genome-wide linkage scans were being used to detect …

Over 200,000 new prostate cancer cases are diagnosed in the United States each year,
accounting for more than 35% of all cancer cases affecting men, and resulting in 40,000 …

BACKGROUND Little is known regarding the clinical features of hereditary prostate
carcinoma (HPC) and whether other malignancies are associated with this disease. The aim …

A previous linkage study provided evidence for a prostate cancer–susceptibility locus at
1q24-25. Subsequent reports in additional collections of families have yielded conflicting …

BACKGROUND Prostate cancer linkage studies have been used to localize rare and
presumably highly penetrant cancer susceptibility genes. Underlying genetic heterogeneity …

In a recent study of 91 families having at least three first degree relatives with prostate
cancer, we reported the localization of a major susceptibility locus for prostate cancer …

Abstract Objectives The Swedish Family-Cancer Database has been the major source of
population-based prospective data on familial risks on most cancers, including prostate …

A family history of prostate cancer increases the risk that a man will develop the disease.
The level of risk when a family member is affected is similar in breast and prostate cancers …

Objective Prostate cancer is the second most frequent cancer in men worldwide and kills
over 250,000 men worldwide every year. Prostate cancer is a heterogeneous disease at the …