In vivo and in vitro treatment of HTLV-1 and HTLV-2 infected cells with arsenic trioxide and interferon-a

R Mahieux, O Hermine - Leukemia & lymphoma, 2005 - Taylor & Francis
Adult T-cell leukemia/lymphoma (ATLL) is a malignant lymphoproliferation of mature
activated T-cells, mostly CD4, which develops after a long period of latency following Human …

Arsenic trioxyde in the treatment of HTLV1 associated ATLL

F Suarez, A Marcais, D Ghez, R Delarue… - Retrovirology, 2011 - Springer
Background The prognosis of Adult T-cell leukemia/lymphoma (ATLL) associated with
HTLV1 is dismal. The response to conventional chemotherapy ranges between 20 and 70 …

Treatment of adult T-cell leukaemia/lymphoma: current strategy and future perspectives

A Bazarbachi, O Hermine - Virus Research, 2001 - Elsevier
Human T-cell leukaemia virus type I (HTLV-I) associated adult T-cell leukaemia/lymphoma
(ATL) carries a very poor prognosis due to an intrinsic resistance of leukaemic cells to …

Arsenic Trioxide and Interferon- Synergize to Induce Cell Cycle Arrest and Apoptosis in Human T-Cell Lymphotropic Virus Type I–Transformed Cells

A Bazarbachi, ME El-Sabban, R Nasr… - Blood, The Journal …, 1999 - ashpublications.org
Human T-cell lymphotropic virus type I (HTLV-I) is the causative agent of adult T-cell
leukemia/lymphoma (ATL). ATL is an aggressive proliferation of mature activated T cells …

[PDF][PDF] Phase II trial of arsenic trioxide and alpha interferon in patients with relapsed/refractory adult T-cell leukemia/lymphoma

P Rousselot, G Damaj, R Delarue… - The Hematology …, 2004 - academia.edu
Human T-cell lymphotropic virus type 1 associated adult T-cell leukemia/lymphoma carries a
very poor prognosis due to its intrinsic resistance to chemotherapy. Although zidovudine …

Treatment of adult T‐cell leukemia/lymphoma: past, present, and future

K Ishitsuka, K Tamura - European journal of haematology, 2008 - Wiley Online Library
Adult T‐cell leukemia/lymphoma (ATLL) is a peripheral T‐cell malignancy caused by human
T‐cell lymphotrophic virus type I. Clinical manifestations of ATLL range from smoldering to …

Arsenic trioxide induces apoptosis in human T-cell leukemia virus type 1–and type 2–infected cells by a caspase-3–dependent mechanism involving Bcl-2 cleavage

R Mahieux, C Pise-Masison, A Gessain… - Blood, The Journal …, 2001 - ashpublications.org
Abstract Treatment of patients with adult T-cell leukemia–lymphoma (ATLL) using
conventional chemotherapy has limited benefit because human T-cell leukemia virus type 1 …

Clinical trials and treatment of ATL

K Tsukasaki, K Tobinai - Leukemia research and treatment, 2012 - Wiley Online Library
ATL is a distinct peripheral T‐lymphocytic malignancy associated with human T‐cell
lymphotropic virus type I (HTLV‐1). The diversity in clinical features and prognosis of …

Emodin and DHA potently increase arsenic trioxide interferon-α–induced cell death of HTLV-I–transformed cells by generation of reactive oxygen species and …

M Brown, M Bellon, C Nicot - Blood, 2007 - ashpublications.org
Adult T-cell leukemia (ATL) is an aggressive lymphoproliferative disease of poor clinical
prognosis associated with infection by the human T-cell leukemia virus type I (HTLV-I). The …

In vitro effects of arsenic trioxide, interferon α and zidovudine in adult T cell leukemia/lymphoma cells

M Hachiman, M Yoshimitsu, C Ezinne… - Oncology …, 2018 - spandidos-publications.com
Despite the efficacy of combination chemotherapy with arsenic trioxide (ATO), interferon α
(IFN) and zidovudine (AZT) for adult T cell leukemia/lymphoma (ATL), the precise …