This systematic review of the effects of bisphosphonate treatment in children with
osteogenesis imperfecta was conducted using the American Academy for Cerebral Palsy …

Objective. Several studies have reported beneficial effects of bisphosphonates in children
with osteogenesis imperfecta (OI); however, these studies have differed in the protocols they …

Abstract Background/Aims: To systematically assess contemporary knowledge regarding the
effectiveness and safety of bisphosphonates (BPs) in children with osteogenesis imperfecta …

Treatment with bisphosphonates has brought significant clinical improvements for children
and adolescents suffering from moderate to severe forms of osteogenesis imperfecta (OI) …

Osteogenesis imperfecta (OI) is a rare genetic connective tissue disorder that results in bone
fragility and deformity. Management is multi disciplinary. Although pharmacologic …

Children with osteogenesis imperfecta (OI) suffer recurrent fractures resulting in pain,
deformity and disability. There is no accepted medical therapy for the condition other than …

Until recently, medical management of osteogenesis imperfecta, a genetic disorder of
reduced bone mass and frequent fractures, was elusive, and treatment was focused on …

INTRODUCTION: Bone mineral density (BMD) and fracture rates in children with
osteogenesis imperfecta (OI) have been shown to improve with bisphosphonate therapy …

Bone mineral density and fracture rates in children with osteogenesis imperfecta improve
with intravenous bisphosphonates. The efficacy of oral bisphosphonates has not been …

Cyclical intravenous bisphosphonate therapy is widely used to treat children with
osteogenesis imperfecta (OI), but little is known about long‐term treatment outcomes. We …