Sources of reactive O2 species in the vessel wall that potentially contribute to the control of
vascular tone include NADPH oxidases, arachidonic acid metabolizing enzymes, xanthine …

Heme oxygenase (HO)-1 induction can attenuate the development of angiotensin II (ANG II)-
dependent hypertension. However, the mechanism by which HO-1 lowers blood pressure is …

Endothelial dysfunction/activation underlies the development of long-term cardiovascular
complications and atherosclerosis. The aim of this study was to examine a direct role for …

BACKGROUND: An altered arterial nitric oxide (NO) pathway could partly explain the
damage to arteries observed in haemodialyzed (HD) patients. The present study was …

Nitric oxide (NO) and superoxide are both constitutive products of the endothelium. Because
NO is readily inactivated by superoxide, the bioactivity of endothelium-derived NO (EDNO) is …

Objective: Oxidative stress has increasingly been implicated in the development and
progression of many vascular diseases. Previous work from our laboratory indicated that …

The macula densa detects changes in NaCl concentration in tubular fluid and transmits a
feedback signal, known as tubuloglomerular feedback (TGF), which helps to control …

The main sources of oxidative stress in the vessel wall are nicotine adenine dinucleotide
phosphate (NADPH) oxidase (Nox) complexes. The endothelium mainly expresses the …

Hypoxia following arteriovenous fistulization results in venous neointimal hyperplasia
(VNH), potentially causing early arteriovenous fistula (AVF) dysfunction. In this study, we …

Pro-inflammatory activation of vascular endothelium is implicated in pathogenesis of severe
conditions including stroke, infarction and sepsis. We have recently reported that superoxide …