Highlights•Grafted neural stem cells extend high numbers of axons over long distances after
spinal cord injury.•Graft derived axons make synaptic connections with host neurons.•Host …

Spinal cord injury (SCI) leads to irreversible functional impairment caused by neuronal loss
and the disruption of neuronal connections across the injury site. While several experimental …

Stem cells, especially neural stem cells (NSCs), are a very attractive cell source for potential
reconstruction of injured spinal cord though either neuroprotection, neural regeneration …

Spinal cord injury (SCI) typically results in long-lasting functional deficits, largely due to
primary and secondary wh ite matter damage at the site of injury. The transplantation of …

Spinal cord injury remains a scientific and therapeutic challenge with great cost to
individuals and society. The goal of research in this field is to find a means of restoring lost …

Spinal cord injury (SCI) causes the irreversible loss of spinal cord parenchyma including
astroglia, oligodendroglia and neurons. In particular, severe injuries can lead to an almost …

Spinal cord injury (SCI) often induces loss of motor and/or sensory function below the level
of injury. While deficits persist in complete lesions, partial lesions of the spinal cord can be …

The implantation of exogenous cells or tissues has been a popular and successful strategy
to overcome physical discontinuity and support axon growth in experimental models of …

Spinal cord injury (SCI) affects millions of individuals worldwide. Currently, there is no cure,
and treatment options to promote neural recovery are limited. An innovative approach to …

(A) Cartoon of the intact spinal cord depicting an ascending sensory axon (blue) originating
in the dorsal root ganglion (DRG), and a descending motor axon (red) originating from …