By 2020, two-thirds of the global burden of disease will be attributable to chronic non-
communicable diseases (eg cardiovascular disease and diabetes), most of them strongly …

Objective: Reports on the immediate and long‐term responses to high‐fat and high‐calorie
(HFC) feeding are controversial. Therefore, we examined the sequential effects of an HFC …

Background: Metabolic disorders are commonly investigated using knockout and transgenic
mouse models on the C57BL/6N genetic background due to its genetic susceptibility to the …

The aim of this study was to characterize the responses of individual tissues to high-fat
feeding as a function of mass, fat composition, and transcript abundance. We examined a …

The sharp increase in obesity prevalence worldwide is mainly attributable to changes in
physical activity and eating behavior but the metabolic and clinical impacts of these …

Overweight and obesity are increasingly common public health issues worldwide, leading to
a wide range of diseases from metabolic syndrome to steatohepatitis and cardiovascular …

Abstract Inbred C57BL/6J mice displayed large individual variations in weight gain when fed
a high-fat diet (HFD). The objective of this study was to examine whether this predominantly …

Background Low-carbohydrate diet (LCD) is effective for weight loss and glycaemic control
in humans. Here, the study aimed to explore the effects of LCD/high-fat diet (HFD) in both …

Diet has a significant impact on human health, yet it is poorly represented or significantly
oversimplified in most preclinical animal studies. A majority of animals used in preclinical …

The aim of this study was to characterize the responses of individual tissues to high fat 23
feeding as a function of mass, fat composition and transcript abundance. We examined a 24 …