In 1997, McPherron et al. created the so-called Mighty Mouse: owing to the knock-out of a
new member of the TGF-β superfamily of peptides, this mouse line was extremely …

In recent years, there has been an increasing interest in myostatin, a hormone that inhibits
the growth and differentiation of muscle tissue. This interest is associated with an increase in …

Myostatin is a powerful negative regulator of skeletal muscle mass in mammalian species. It
plays a key role in skeletal muscle homeostasis and has now been well described since its …

The presence of sufficient skeletal muscle mass is of paramount importance for body
function and the myostatin cascade is known to inhibit muscle growth in mammals. In …

A significant proportion of heart failure patients develop skeletal muscle wasting and cardiac
cachexia, which is associated with a very poor prognosis. Recently, myostatin, a cytokine …

Myostatin is a member of the transforming growth factor (TGF)-β superfamily. It is expressed
by animal and human skeletal muscle cells where it limits muscle growth and promotes …

Mutations in the myostatin gene are associated with hypermuscularity, suggesting that
myostatin inhibits skeletal muscle growth. We postulated that increased tissue-specific …

Myostatin is a negative regulator of muscle mass. Important advances in our understanding
of the complex biology of this factor have revealed the therapeutic potential of antagonizing …

Myostatin (Mst) is a negative regulator of skeletal muscle in humans and animals. It is
moderately expressed in the heart of sheep and cattle, increasing considerably after …

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