The pancreatic islet is a highly specialized tissue embedded in the exocrine pancreas
whose primary function is that of controlling glucose homeostasis. Thus, understanding the …

Human genetic studies have emphasised the dominant contribution of pancreatic islet
dysfunction to development of Type 2 Diabetes (T2D). However, limited annotation of the …

Genome-wide association studies (GWASs) identified hundreds of signals associated with
type 2 diabetes (T2D). To gain insight into their underlying molecular mechanisms, we have …

Type 2 diabetes affects over 300 million people, causing severe complications and
premature death, yet the underlying molecular mechanisms are largely unknown. Pancreatic …

Identifying cis-regulatory elements is important to understanding how human pancreatic
islets modulate gene expression in physiologic or pathophysiologic (eg, diabetic) conditions …

Genetic variation can modulate gene expression, and thereby phenotypic variation and
susceptibility to complex diseases such as type 2 diabetes (T2D). Here we harnessed the …

Most signals detected by genome-wide association studies map to non-coding sequence
and their tissue-specific effects influence transcriptional regulation. However, many key …

Abstract Purpose of Review Common genetic variants that associate with type 2 diabetes
risk are markedly enriched in pancreatic islet transcriptional enhancers. This review …

Genome-wide association studies (GWAS) have identified> 100 independent SNPs that
modulate the risk of type 2 diabetes (T2D) and related traits. However, the pathogenic …

Characterization of gene expression in pancreatic islets and its alteration in type 2 diabetes
(T2D) are vital in understanding islet function and T2D pathogenesis. We leveraged RNA …