Changes in hippocampal GABABR1 subunit expression in Alzheimer's patients: association with Braak staging

M Iwakiri, K Mizukami, MD Ikonomovic, M Ishikawa… - Acta …, 2005 - Springer
Alterations in the γ-aminobutyric acid (GABA) neurotransmitter and receptor systems may
contribute to vulnerability of hippocampal pyramidal neurons in Alzheimer's disease (AD) …

An immunohistochemical study of GABAA receptor gamma subunits in Alzheimer's disease hippocampus: Relationship to neurofibrillary tangle progression

M Iwakiri, K Mizukami, MD Ikonomovic… - …, 2009 - Wiley Online Library
Immunohistochemical characterization of the distribution of GABAA receptor subunits γ1/3
and 2 in the hippocampus relative to neurofibrillary tangle (NFT) pathology staging was …

Immunohistochemical study of GABAAReceptor β2/3 subunits in the hippocampal formation of aged brains with Alzheimer-related Neuropathologic changes

K Mizukami, MD Ikonomovic, DR Grayson… - Experimental …, 1997 - Elsevier
In AD, it is hypothesized that one factor contributing to the vulnerability of neurons is a
delicate balance of excitatory and inhibitory inputs. To examine this hypothesis we have …

GABAA receptor β2 and β3 subunits mRNA in the hippocampal formation of aged human brain with Alzheimer-related neuropathology

K Mizukami, DR Grayson, MD Ikonomovic… - Molecular brain …, 1998 - Elsevier
Our work on the role of glutamate in Alzheimer's disease (AD)-related neuronal vulnerability
and death provided significant insight into the potential contribution of the γ-aminobutyric …

GABAA receptor subunit expression changes in the human Alzheimer's disease hippocampus, subiculum, entorhinal cortex and superior temporal gyrus

A Kwakowsky, B Calvo‐Flores Guzmán… - Journal of …, 2018 - Wiley Online Library
Gamma‐aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central
nervous system. GABA type A receptors (GABAAR s) are severely affected in Alzheimer's …

Immunohistochemical study of GABAA receptor α1 subunit in the hippocampal formation of aged brains with Alzheimer-related neuropathologic changes

K Mizukami, MD Ikonomovic, DR Grayson, R Sheffield… - Brain research, 1998 - Elsevier
Immunocytochemical techniques were employed to examine the distribution of the γ-
aminobutyric acid (GABA) A receptor α1 subunit within the hippocampus of 19 elderly …

Biochemical analysis of GABAA receptor subunits α1, α5, β1, β2 in the hippocampus of patients with Alzheimer's disease neuropathology

RA Rissman, AJ Mishizen-Eberz, TL Carter, BB Wolfe… - Neuroscience, 2003 - Elsevier
Alzheimer's disease (AD) is characterized by selective vulnerability of specific neuronal
populations within particular brain regions. For example, hippocampal glutamatergic cell …

Impaired expression of GABA signaling components in the Alzheimer's disease middle temporal gyrus

K Govindpani, C Turner, HJ Waldvogel… - International journal of …, 2020 - mdpi.com
γ-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter, playing a central role
in the regulation of cortical excitability and the maintenance of the excitatory/inhibitory (E/I) …

Gamma-aminobutyric acid A receptors in Alzheimer's disease: highly localized remodeling of a complex and diverse signaling pathway

A Kwakowsky, BCF Guzmán… - Neural regeneration …, 2018 - journals.lww.com
Conclusions: Our findings demonstrated that the GABAergic system suffers significant
remodeling in the brains of AD patients, yet it is to be determined if this is as a consequence …

Density of GABAB Receptors Is Reduced in Granule Cells of the Hippocampus in a Mouse Model of Alzheimer's Disease

A Martín-Belmonte, C Aguado, R Alfaro-Ruíz… - International journal of …, 2020 - mdpi.com
Metabotropic γ-aminobutyric acid (GABAB) receptors contribute to the control of network
activity and information processing in hippocampal circuits by regulating neuronal …