Background Tumor heterogeneity is a major obstacle for finding effective treatment of
Glioblastoma (GBM). Based on global expression analysis, GBM can be classified into …

Dear Editor, Tumour recurrence is the leading cause of glioma mortality. Current therapies
based on excised tumour tissues cannot be lastingly effective due to the waning …

Platelet derived growth factor receptors (PDGFRs) play an important role in tumor
pathogenesis, and they are frequently overexpressed in glioblastoma (GBM). Earlier we …

Modeling brain tumor formation in experimental animals with somatic cell gene transfer has
a long history. In the early experiments naturally occurring retroviruses were used to induce …

Retroviruses have been foundational in cancer research since early studies identified proto-
oncogenes as targets for insertional mutagenesis. Integration of murine gamma-retroviruses …

Studies of gene rearrangements and the consequent oncogenic fusion proteins have laid
the foundation for targeted cancer therapy. To identify oncogenic fusions associated with …

Glioblastoma multiforme (GBM) is the most common and aggressive type of primary brain
tumor. Epidermal growth factor (EGF) and platelet‐derived growth factor (PDGF) receptors …

Retroviral insertional mutagenesis in mouse hematopoietic tumors provides a potent cancer
gene discovery tool in the post‐genome‐sequence era. To manage multiple high …

Despite an improved understanding of the molecular aberrations that occur in glioblastoma,
the use of molecularly targeted therapies have so far been disappointing. We present a …

Glioblastoma (GBM) is the most common malignant adult primary brain tumor. Despite its
high lethality, a small proportion of patients have a relatively long overall survival (OS). Here …