Cardiovascular disease is a leading cause of death worldwide and is associated with
systemic inflammation. In depth study of the cell-specific signaling mechanisms mediating …

BACKGROUND: Cardiac inflammation in heart failure is characterized by the presence of
damage-associated molecular patterns, myeloid cells, and T cells. Cardiac damage …

Background—Experimental autoimmune myocarditis (EAM) is a CD4+ T-cell–mediated
mouse model of postviral cardiomyopathy. Activation of interleukin-1 type 1 and Toll-like …

MyD88 is the canonical adaptor for inflammatory signaling pathways downstream of
members of the Toll-like receptor (TLR) and interleukin-1 (IL-1) receptor families. MyD88 …

Introduction: Myeloid differentiation primary response protein 88 (MyD88) is a critical
adaptor protein involved in Toll-like and IL-1 receptor family signaling controlling innate …

Atherosclerosis, the leading cause of death in developed countries, has been linked to
hypercholesterolemia for decades. More recently, atherosclerotic lesion progression has …

Myeloid differentiation factor 88 (MyD88), an adaptor critical for innate immune function,
plays a role in neutrophil recruitment and myocardial injury after transient ischemia …

Detection of self nucleic acids by Toll-like receptors (TLR) preciptates autoimmune diseases,
including systemic lupus erythematosus (SLE). It remains unknown how TLR signals in …

The continuous emergence of infectious pathogens along with antimicrobial resistance
creates a need for an alternative approach to treat infectious diseases. Targeting host factor …

Rationale: The myeloid differentiation factor (MyD) 88/interleukin (IL)-1 axis activates self–
antigen-presenting cells and promotes autoreactive CD4+ T-cell expansion in experimental …