[HTML][HTML] Osteoarthritis: a narrative review of molecular approaches to disease management

LA Salman, G Ahmed, SG Dakin, B Kendrick… - Arthritis Research & …, 2023 - Springer
Osteoarthritis (OA) is a chronic, progressive degenerative whole joint disease that affects the
articular cartilage, subchondral bone, ligaments, capsule, and synovium. While it is still …

Current advances in therapies for osteoarthritis

KC Kalunian - Current Opinion in Rheumatology, 2016 - journals.lww.com
Current advances in therapies for osteoarthritis : Current Opinion in Rheumatology Current
advances in therapies for osteoarthritis : Current Opinion in Rheumatology Log in or Register …

[HTML][HTML] Osteoarthritis: novel molecular mechanisms increase our understanding of the disease pathology

S Grässel, F Zaucke, H Madry - Journal of clinical medicine, 2021 - mdpi.com
Although osteoarthritis (OA) is the most common musculoskeletal condition that causes
significant health and social problems worldwide, its exact etiology is still unclear. With an …

[PDF][PDF] Osteoarthritis pathophysiology: therapeutic target discovery may require a multifaceted approach

TL Vincent, T Alliston, M Kapoor, RF Loeser… - Clinics in geriatric …, 2022 - Elsevier
Molecular understanding of osteoarthritis (OA) has greatly increased over the past 15 years
through careful analysis of tissue samples, pre-clinical models and large-scale agnostic '∼ …

Emerging targets in osteoarthritis therapy

MB Goldring, F Berenbaum - Current opinion in pharmacology, 2015 - Elsevier
Highlights•Different OA etiologies present a challenge for developing a single targeted
therapy.•Common mechanisms occur in inflammatory, mechanical, and oxidative stress in …

[HTML][HTML] Therapeutics in osteoarthritis based on an understanding of its molecular pathogenesis

JR Kim, JJ Yoo, HA Kim - International journal of molecular sciences, 2018 - mdpi.com
Osteoarthritis (OA) is the most prevalent joint disease in older people and is characterized
by the progressive destruction of articular cartilage, synovial inflammation, changes in …

[PDF][PDF] Future directions for research and treatment of osteoarthritis

CJ Malemud, VM Goldberg - Front Biosci, 1999 - article.imrpress.com
[Frontiers in Bioscience 4, d762-771, October 15, 1999] 762 FUTURE DIRECTIONS FOR
RESEARCH AND TREATMENT OF OSTEOARTHRITIS Charl Page 1 [Frontiers in Bioscience 4 …

Recent advances in the understanding of molecular mechanisms of cartilage degeneration, synovitis and subchondral bone changes in osteoarthritis

Y Wei, L Bai - Connective tissue research, 2016 - Taylor & Francis
Osteoarthritis (OA), the most common form of degenerative joint disease, is linked to high
morbidity. It is predicted to be the single greatest cause of disability in the general population …

Pathobiology of osteoarthritis: pathomechanisms and potential therapeutic targets

HI Roach, T Aigner, S Soder, J Haag… - Current Drug …, 2007 - ingentaconnect.com
Osteoarthritis, a degenerative joint disease, is the most disabling condition of the Western
world. It affects first and foremost the articular cartilages and leads to a molecular and …

[HTML][HTML] The hallmarks of osteoarthritis and the potential to develop personalised disease-modifying pharmacological therapeutics

DP Tonge, MJ Pearson, SW Jones - Osteoarthritis and cartilage, 2014 - Elsevier
Osteoarthritis (OA) is an age-related condition and the leading cause of pain, disability and
shortening of adult working life in the UK. The incidence of OA increases with age, with 25 …