A wide variety of therapeutic agents may benefit by specifically directing them to the
mitochondria in tumor cells. The current work aimed to design delivery systems that would …

Mitochondrial-oriented delivery of anticancer drugs has been considered as a promising
strategy to improve the antitumor efficiency of chemotherapeutics. However, the …

The mitochondrion is an important intracellular organelle for drug targeting due to its key
roles and functions in cellular proliferation and death. In the last few decades, several …

Bioactivable nanocarrier systems have favorable characteristics such as high cellular
uptake, target specificity, and an efficient intracellular release mechanism. In this study, we …

Targeting drugs at mitochondria may provide an effective means of inducing cell death for
cancer therapy. Here, we introduce a conjugate of a dual-ligand-modified N-(2 …

The mitochondrion is a dynamic eukaryotic organelle that controls lethal and vital functions
of the cell. Being a critical center of metabolic activities and involved in many diseases …

Poor anti-metastasis effects and side-effects remain a challenge for the clinical application of
camptothecin (CPT). Mitochondria can be a promising target for the treatment of metastatic …

The importance of mitochondrial delivery of an anticancer drug to cancer cells has been
recognized to improve therapeutic efficacy. The introduction of lipophilic cations, such as …

Primary tumor metastasis remains to be a tough obstacle for clinical breast cancer treatment.
Since evidences have shown that mitochondria play a crucial role in tumor metastasis, we …

Mitochondrial drug delivery systems require development of highly selective mitochondria-
targeting carriers. In this study, we report that mitochondria targeting sequence (MTS)-hybrid …