Contribution of autophagy machinery factors to HCV and SARS-CoV-2 replication organelle formation
Positive-strand RNA viruses replicate in close association with rearranged intracellular
membranes. For hepatitis C virus (HCV) and severe acute respiratory syndrome coronavirus …
membranes. For hepatitis C virus (HCV) and severe acute respiratory syndrome coronavirus …
The inherent dynamics and interaction sites of the SARS-CoV-2 nucleocapsid N-terminal region
JS Redzic, E Lee, A Born, A Issaian, MA Henen… - Journal of Molecular …, 2021 - Elsevier
The nucleocapsid protein is one of four structural proteins encoded by SARS-CoV-2 and
plays a central role in packaging viral RNA and manipulating the host cell machinery, yet its …
plays a central role in packaging viral RNA and manipulating the host cell machinery, yet its …
Nanometer-resolution in situ structure of the SARS-CoV-2 postfusion spike protein
L Tai, G Zhu, M Yang, L Cao, X Xing… - Proceedings of the …, 2021 - National Acad Sciences
The spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
mediates membrane fusion to allow entry of the viral genome into host cells. To understand …
mediates membrane fusion to allow entry of the viral genome into host cells. To understand …
[HTML][HTML] SARS-CoV-2 nucleocapsid protein undergoes liquid-liquid phase separation stimulated by RNA and partitions into phases of human ribonucleoproteins.
Tightly packed complexes of nucleocapsid protein and genomic RNA form the core of
viruses and may assemble within viral factories, dynamic compartments formed within the …
viruses and may assemble within viral factories, dynamic compartments formed within the …
[HTML][HTML] SARS-CoV-2 nucleocapsid protein binds host mRNAs and attenuates stress granules to impair host stress response
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleocapsid (N) protein is
essential for viral replication, making it a promising target for antiviral drug and vaccine …
essential for viral replication, making it a promising target for antiviral drug and vaccine …
The SARS-CoV-2 envelope and membrane proteins modulate maturation and retention of the spike protein, allowing assembly of virus-like particles
B Boson, V Legros, B Zhou, E Siret, C Mathieu… - Journal of Biological …, 2021 - ASBMB
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a β-coronavirus, is the
causative agent of the COVID-19 pandemic. Like for other coronaviruses, its particles are …
causative agent of the COVID-19 pandemic. Like for other coronaviruses, its particles are …
A unifying structural and functional model of the coronavirus replication organelle: Tracking down RNA synthesis
EJ Snijder, RWAL Limpens, AH de Wilde… - PLoS …, 2020 - journals.plos.org
Zoonotic coronavirus (CoV) infections, such as those responsible for the current severe
acute respiratory syndrome-CoV 2 (SARS-CoV-2) pandemic, cause grave international …
acute respiratory syndrome-CoV 2 (SARS-CoV-2) pandemic, cause grave international …
SARS-CoV-2 nucleocapsid protein impairs stress granule formation to promote viral replication
ZQ Zheng, SY Wang, ZS Xu, YZ Fu, YY Wang - Cell Discovery, 2021 - nature.com
The newly emerging coronavirus SARS-CoV-2 causes severe lung disease and substantial
mortality. How the virus evades host defense for efficient replication is not fully understood …
mortality. How the virus evades host defense for efficient replication is not fully understood …
Reticulons promote formation of ER-derived double-membrane vesicles that facilitate SARS-CoV-2 replication
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the etiologic agent for the
global COVID-19 pandemic, triggers the formation of endoplasmic reticulum (ER)-derived …
global COVID-19 pandemic, triggers the formation of endoplasmic reticulum (ER)-derived …
Understanding the phase separation characteristics of nucleocapsid protein provides a new therapeutic opportunity against SARS-CoV-2
To date, tens of millions of people have been infected with severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), causing the outbreak of the respiratory disease …
syndrome coronavirus 2 (SARS-CoV-2), causing the outbreak of the respiratory disease …