Contribution of autophagy machinery factors to HCV and SARS-CoV-2 replication organelle formation

WI Twu, JY Lee, H Kim, V Prasad, B Cerikan… - Cell reports, 2021 - cell.com
Positive-strand RNA viruses replicate in close association with rearranged intracellular
membranes. For hepatitis C virus (HCV) and severe acute respiratory syndrome coronavirus …

The inherent dynamics and interaction sites of the SARS-CoV-2 nucleocapsid N-terminal region

JS Redzic, E Lee, A Born, A Issaian, MA Henen… - Journal of Molecular …, 2021 - Elsevier
The nucleocapsid protein is one of four structural proteins encoded by SARS-CoV-2 and
plays a central role in packaging viral RNA and manipulating the host cell machinery, yet its …

Nanometer-resolution in situ structure of the SARS-CoV-2 postfusion spike protein

L Tai, G Zhu, M Yang, L Cao, X Xing… - Proceedings of the …, 2021 - National Acad Sciences
The spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
mediates membrane fusion to allow entry of the viral genome into host cells. To understand …

[HTML][HTML] SARS-CoV-2 nucleocapsid protein undergoes liquid-liquid phase separation stimulated by RNA and partitions into phases of human ribonucleoproteins.

TM Perdikari, AC Murthy, VH Ryan, S Watters, MT Naik… - BioRxiv, 2020 - ncbi.nlm.nih.gov
Tightly packed complexes of nucleocapsid protein and genomic RNA form the core of
viruses and may assemble within viral factories, dynamic compartments formed within the …

[HTML][HTML] SARS-CoV-2 nucleocapsid protein binds host mRNAs and attenuates stress granules to impair host stress response

S Nabeel-Shah, H Lee, N Ahmed, GL Burke… - IScience, 2022 - cell.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleocapsid (N) protein is
essential for viral replication, making it a promising target for antiviral drug and vaccine …

The SARS-CoV-2 envelope and membrane proteins modulate maturation and retention of the spike protein, allowing assembly of virus-like particles

B Boson, V Legros, B Zhou, E Siret, C Mathieu… - Journal of Biological …, 2021 - ASBMB
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a β-coronavirus, is the
causative agent of the COVID-19 pandemic. Like for other coronaviruses, its particles are …

A unifying structural and functional model of the coronavirus replication organelle: Tracking down RNA synthesis

EJ Snijder, RWAL Limpens, AH de Wilde… - PLoS …, 2020 - journals.plos.org
Zoonotic coronavirus (CoV) infections, such as those responsible for the current severe
acute respiratory syndrome-CoV 2 (SARS-CoV-2) pandemic, cause grave international …

SARS-CoV-2 nucleocapsid protein impairs stress granule formation to promote viral replication

ZQ Zheng, SY Wang, ZS Xu, YZ Fu, YY Wang - Cell Discovery, 2021 - nature.com
The newly emerging coronavirus SARS-CoV-2 causes severe lung disease and substantial
mortality. How the virus evades host defense for efficient replication is not fully understood …

Reticulons promote formation of ER-derived double-membrane vesicles that facilitate SARS-CoV-2 replication

JM Williams, YJ Chen, WJ Cho, AW Tai, B Tsai - Journal of Cell Biology, 2023 - rupress.org
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the etiologic agent for the
global COVID-19 pandemic, triggers the formation of endoplasmic reticulum (ER)-derived …

Understanding the phase separation characteristics of nucleocapsid protein provides a new therapeutic opportunity against SARS-CoV-2

D Zhao, W Xu, X Zhang, X Wang, Y Ge, E Yuan… - Protein & …, 2021 - academic.oup.com
To date, tens of millions of people have been infected with severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), causing the outbreak of the respiratory disease …